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Complications
By Mayo Clinic staffTriple X syndrome can cause developmental delays or learning disabilities, and it's possible that learning disabilities or delayed development could eventually lead to a variety of other issues, including academic problems, stress and poor socialization skills that cause social isolation.
Other possible, though much rarer, complications that may occur include:
- Premature ovarian failure or ovary abnormalities. When the ovaries stop working before the expected age of menopause, there's a decline in the production of certain hormones and eggs are no longer released by the ovaries each month. This can cause infertility. Additionally, girls and women with triple X syndrome may have malformed ovaries.
- Seizures. Girls and women with triple X syndrome may develop a seizure disorder.
- Kidney abnormalities. Females born with triple X syndrome may also have abnormally developed kidneys or may have only one kidney.
- Otter M, et al. Triple X syndrome: A review of the literature. European Journal of Human Genetics. 2010;18:265.
- Triple X syndrome. U.S. National Library of Medicine's Genetics Home Reference. http://ghr.nlm.nih.gov/condition/triple-x-syndrome. Accessed June 14, 2010.
- Tartaglia NR, et al. A review of trisomy X (47,XXX). Orphanet Journal of Rare Diseases. 2010;5:8.
- Lalatta F, et al. Triple X syndrome: Characteristics of 42 Italian girls and parental emotional response to prenatal diagnosis. European Journal of Pediatrics. In press. Accessed June 14, 2010.
- Zabel CA (expert opinion). Mayo Clinic, Rochester, Minn. July 6, 2010.
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