DefinitionBy Mayo Clinic staff
Tuberculosis (TB) is a potentially serious infectious disease that mainly affects your lungs. The bacteria that cause tuberculosis are spread from one person to another through tiny droplets released into the air via coughs and sneezes.
Once rare in developed countries, tuberculosis infections began increasing in 1985, partly because of the emergence of HIV, the virus that causes AIDS. HIV weakens a person's immune system so it can't fight the TB germs. In the United States, because of stronger control programs, tuberculosis began to decrease again in 1993, but remains a concern.
Many strains of tuberculosis resist the drugs most used to treat the disease. People with active tuberculosis must take several types of medications for many months to eradicate the infection and prevent development of antibiotic resistance.
- Questions and answers about tuberculosis. Centers for Disease Control and Prevention. http://www.cdc.gov/tb/publications/faqs/pdfs/qa.pdf. Accessed Oct. 16, 2012.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed Oct. 16, 2012.
- Sterling TR, et al. Three months of rifapentine and isoniazid for latent tuberculosis infection. New England Journal of Medicine. 2011;365:2155.
- Druszczynska M, et al. Latent M. tuberculosis infection - pathogenesis, diagnosis, treatment and prevention strategies. Polish Journal of Microbiology. 2012;61:3.
- Coussens AK, et al. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. Proceedings of the National Academy of Sciences. 2012;109:15449.
- Lawn SD, et al. Tuberculosis in antiretroviral treatment services in resource-limited settings: Addressing the challenges of screening and diagnosis. Journal of Infectious Diseases. 2011;204:S1159.
- Tuberculosis. World Health Organization. http://www.who.int/mediacentre/factsheets/fs104/en/index.html. Accessed Oct.23, 2012.
- Ferri FF. Ferri's Clinical Advisor 2013: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-0-323-08373-7..00002-9&isbn=978-0-323-08373-7&about=true&uniqId=343863096-23. Accessed Oct. 16, 2012.