Tuberculosis

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Symptoms

By Mayo Clinic staff

Although your body may harbor the bacteria that cause tuberculosis, your immune system often can prevent you from becoming sick. For this reason, doctors make a distinction between:

  • Latent TB. In this condition, you have a TB infection, but the bacteria remain in your body in an inactive state and cause no symptoms. Latent TB, also called inactive TB or TB infection, isn't contagious.
  • Active TB. This condition makes you sick and can spread to others.

Signs and symptoms of active TB include:

  • Unexplained weight loss
  • Fatigue
  • Fever
  • Night sweats
  • Chills
  • Loss of appetite

Tuberculosis usually attacks your lungs. Signs and symptoms of TB of the lungs include:

  • Coughing that lasts three or more weeks
  • Coughing up blood
  • Chest pain, or pain with breathing or coughing

Tuberculosis can also affect other parts of your body, including your kidneys, spine or brain. When TB occurs outside your lungs, symptoms vary according to the organs involved. For example, tuberculosis of the spine may give you back pain, and tuberculosis in your kidneys might cause blood in your urine.

When to see a doctor
See your doctor if you have a fever, unexplained weight loss, night sweats and a persistent cough. These are often signs of TB, but they can also result from other medical problems. Your doctor can perform tests to help determine the cause. TB can be diagnosed by your primary care doctor or by a doctor who specializes in lung diseases (pulmonologist) or by an infectious disease specialist. If you don't have a doctor, your local public health department can help.

References
  1. Riley LW. Microbiology and pathogenesis of tuberculosis. http://www.uptodate.com/home/index.html. Accessed Dec. 22, 2008.
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  3. Summary. In: WHO Report 2008: Global tuberculosis control - Surveillance, planning, financing. World Health Organization. Accessed Dec. 20, 2008. http://www.who.int/tb/publications/global_report/2008/summary/en/index.html.
  4. Bass JB Jr. Patient information: Tuberculosis. http://www.uptodate.com/home/index.html. Accessed Dec. 20, 2008.
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  9. Tuberculosis (TB): Symptoms. National Institute of Allergy and Infectious Diseases. http://www3.niaid.nih.gov/topics/tuberculosis/Understanding/symptoms.htm. Accessed Dec. 20, 2008.
  10. Tuberculosis: General information. Centers for Disease Control and Prevention. http://www.cdc.gov/tb/pubs/tbfactsheets/tb.htm. Accessed Dec. 20, 2008.
  11. Bass JB Jr. Risk factors for tuberculosis. http://www.uptodate.com/home/index.html. Accessed Dec. 22, 2008.
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  13. Key points. In: WHO Report 2008: Global tuberculosis control - Surveillance, planning, financing. World Health Organization. http://www.who.int/tb/publications/global_report/2008/key_points/en/index.html. Accessed Dec. 20, 2008.
  14. Tuberculosis (TB): TB and HIV infection. National Institute of Allergy and Infectious Diseases. http://www3.niaid.nih.gov/topics/tuberculosis/Understanding/tbHIV.htm. Accessed Dec. 20, 2008.
  15. Madariaga MG, et al. Extensively drug-resistant tuberculosis. American Journal of Medicine. 2008;121:835.
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  17. Fauci AS, et al. Multidrug-resistant and extensively drug-resistant tuberculosis: The National Institute of Allergy and Infectious Diseases research agenda and recommendations for priority research. Journal of Infectious Diseases. 2008;197:1493.
  18. Tuberculosis (TB): TB definitions. National Institute of Allergy and Infectious Diseases. http://www3.niaid.nih.gov/topics/tuberculosis/Understanding/WhatIsTB/TBdefinitions.htm. Accessed Dec. 20, 2008.
  19. Grant A, et al. Clinical review: Managing drug resistant tuberculosis. BMJ. 2008;337:a1110.
  20. Jeong YJ, et al. Pulmonary tuberculosis: Up-to-date imaging and management. American Journal of Radiology. 2008;191:834.
  21. Pediatric tuberculosis fact sheet. American Lung Association. http://www.lungusa.org/site/apps/nlnet/content3.aspx?c=dvLUK9O0E&b=4294229&ct=3052619. Accessed Dec. 20, 2008.
  22. Diagnosis of tuberculosis disease. Centers for Disease Control and Prevention. http://www.cdc.gov/tb/pubs/tbfactsheets/diagnosis.htm. Accessed Dec. 20, 2008.
  23. Catanzaro A. Rapid diagnostic tests for tuberculosis. http://www.uptodate.com/home/index.html. Accessed Dec. 22, 2008.
  24. Tuberculosis skin test fact sheet. American Lung Association. http://www.lungusa.org/site/apps/nl/content3.asp?c=dvLUK9O0E&b=2060731&content_id={E017092A-511A-4871-8EAE-17988C696509}&notoc=1. Accessed Dec. 20, 2008.
  25. Tuberculosis (TB): Diagnosis. National Institute of Allergy and Infectious Diseases. http://www3.niaid.nih.gov/topics/tuberculosis/Understanding/diagnosis.htm. Accessed Dec. 20, 2008.
  26. TB skin test. Lab Tests Online. http://www.labtestsonline.org/understanding/analytes/tb_skin/. Accessed Dec. 22, 2008.
  27. Zhang Y. Advances in the treatment of tuberculosis. Clinical Pharmacology & Therapeutics. 2007;82:595.
  28.  Menzies D, et al. Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection. Annals of Internal Medicine. 2008;149:689.
  29. HIV and tuberculosis fact sheet. American Lung Association. http://www.lungusa.org/site/apps/nl/content3.asp?c=dvLUK9O0E&b=2060731&content_id=%7bA3132347-3F7C-4ED7-AB4C-34FBEE5B0D4C%7d&notoc=1.
  30. Tuberculosis and pregnancy. Centers for Disease Control and Prevention. http://www.cdc.gov/tb/pubs/tbfactsheets/pregnancy. Accessed Dec. 20, 2008.
  31. Tuberculosis (TB): Prevention. National Institute of Allergy and Infectious Diseases. http://www3.niaid.nih.gov/topics/tuberculosis/Understanding/prevention.htm. Accessed Dec. 20, 2008.

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Jan. 28, 2009

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