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Definition

By Mayo Clinic staff

Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin, a hormone needed to allow sugar (glucose) to enter cells to produce energy. Type 2 diabetes, which is far more common, occurs when the body becomes resistant to the effects of insulin or doesn't make enough insulin.

Various factors may contribute to type 1 diabetes, including genetics and exposure to certain viruses. Although type 1 diabetes typically appears during adolescence, it can develop at any age.

Despite active research, type 1 diabetes has no cure, although it can be managed. With proper treatment, people who have type 1 diabetes can expect to live longer, healthier lives than in the past.

References
  1. Diabetes mellitus (DM). The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec12/ch158/ch158b.html#sec12-ch158-ch158b-1105. Accessed Feb. 22, 2011.
  2. Standards of medical care in diabetes — 2011. Diabetes Care. 2011:34:S11.
  3. Eisenbarth GS, et al. Pathogenesis of type 1 diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Feb. 18, 2011.
  4. Heart disease and stroke statistics — 2009 update. American Heart Association. http://www.americanheart.org/downloadable/heart/123565990943909Heart%20and%20Stroke%20Update.pdf. Accessed Feb. 22, 2011.
  5. Roberts AW. Cardiovascular risk and prevention in diabetes mellitus. Clinical Medicine. 2010;10:495.
  6. Your guide to diabetes: Type 1 and type 2. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/dm/pubs/type1and2/index.htm. Accessed Feb. 22, 2011.
  7. What people with diabetes need to know about osteoporosis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Bone/Osteoporosis/Conditions_Behaviors/diabetes.asp. Accessed Feb. 22, 2011.
  8. Bergenstal RM, et al. Effectiveness of sensor-augmented insulin pump therapy in type 1 diabetes. New England Journal of Medicine. 2010;363:311.
  9. Wahabi HA, et al. Preconception care for diabetic women for improving maternal and fetal outcomes: A systematic review and meta-analysis. BMC Pregnancy and Childbirth. 2010;10:63.
  10. Tieu J, et al. Preconception care for diabetic women for improving maternal and infant health (review). The Cochrane Collection. 2010;12.
  11. Robertson RP. Pancreas and islet transplantation in diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Feb. 22, 2011.
  12. Stem cell information. National Institutes of Health. http://stemcells.nih.gov/info/scireport/chapter7.asp. Accessed Feb. 24, 2011.
  13. National diabetes statistics, 2011. National Diabetes Information Clearinghouse. diabetes.niddk.nih.gov/DM/PUBS/statistics/DM_Statistics.pdf. Accessed Feb. 24. 2011.
  14. Hypoglycemia. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/dm/pubs/hypoglycemia/index.htm. Accessed Feb. 22, 2011.
  15. Diabetic ketoacidosis. National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001363. Accessed Feb. 24, 2011.
  16. Centers for Disease Control and Prevention, et al. Use of hepatitis B vaccine for adults with diabetes mellitus: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommendations and Reports. 2011:60;1709.
DS00329 Jan. 25, 2012

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