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Complications

By Mayo Clinic staff

Although uterine fibroids usually aren't dangerous, they can cause discomfort and may lead to complications such as anemia from heavy blood loss. In rare instances, fibroid tumors can grow out of your uterus on a stalk-like projection. If the fibroid twists on this stalk, you may develop a sudden, sharp, severe pain in your lower abdomen. If so, seek medical care right away. You may need surgery.

Pregnancy and fibroids
Fibroids usually don't interfere with conception and pregnancy. However, it's possible that fibroids could distort or block your fallopian tubes, or interfere with the passage of sperm from your cervix to your fallopian tubes. Submucosal fibroids may prevent implantation and growth of an embryo, and in these cases, doctors often recommend removing these fibroids before attempting pregnancy.

In other cases, treatment for fibroids during pregnancy isn't necessary. A common complication of fibroids during pregnancy is localized pain, typically between the first and second trimesters. This is usually easily treated with pain relievers. But if you have fibroids and you've experienced repeated pregnancy losses, your doctor may recommend removing one or more fibroids to improve your chances of carrying a baby to term, especially if no other causes of miscarriage can be found and if your fibroids distort the shape of your uterine cavity.

References
  1. Haney AF. Leiomyomata. In: Gibb RS, et al. Danforth's Obstetrics and Gynecology. 10th ed. Philadelphia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2008:916.
  2. Baird DD, et al. High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence. American Journal of Obstetrics and Gynecology. 2003;188:100.
  3. Stewart EA. Epidemiology, clinical manifestations, diagnosis, and natural history of uterine leiomyomas. http://www.uptodate.com/home/index.html. Accessed May 17, 2011.
  4. The American College of Obstetricians and Gynecologists. Alternatives to hysterectomy in the management of leiomyomas. Obstetrics & Gynecology. 2008;112:387.
  5. Peddada SD, et al. Growth of uterine leiomyomata among premenopausal black and white women. Proceedings of the National Academy of Sciences of the United States of America. 2010;105:19887.
  6. Laughlin SK, et al. Uterine leiomyomas: Individualizing the approach to a heterogeneous condition. Obstetrics & Gynecology. 2011;117:396.
  7. Uterine fibroids. The American College of Obstetricians and Gynecologists. http://www.acog.org/publications/patient_education/bp074.cfm. Accessed May 17, 2011.
  8. Stewart EA. Pathogenesis of uterine leiomyomas. http://www.uptodate.com/home/index.html. Accessed May 17, 2009.
  9. Management of uterine fibroids: An update of the evidence. Rockville, Md.: Agency for Healthcare Research and Quality. http://www.ahrq.gov/downloads/pub/evidence/pdf/uterupdate/uterup.pdf. Accessed May 17, 2011.
  10. Stewart EA. Overview of treatment of uterine leiomyomas. http://www.uptodate.com/home/index.html. Accessed May 17, 2011.
  11. Marshall LM, et al. A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertility and Sterility. 1998;70:432.
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  13. Chiaffarino F, et al. Use of oral contraceptives and uterine fibroids: Results from a case-control study. British Journal of Obstetrics and Gynaecology. 1999;106:857.
  14. Stewart EA. Alternative and complementary therapies. In: Stewart EA. Uterine Fibroids: The Complete Guide. Baltimore, Md.: Johns Hopkins University Press; 2007:172.
  15. Salman T, et al. Uterine fibroids, management and effect on fertility. Current Opinion in Obstetrics and Gynecology. 2010;22:295.
  16. Al Hilli MM, et al. Magnetic resonance-guided focused ultrasound surgery. Seminars in reproductive medicine. 2010;28:242.
  17. Wise LA, et al. Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: A prospective study. American Journal of Epidemiology. 2004;159:113.
  18. Pritts EA, et al. Fibroids and infertility: An updated systematic review of the evidence. Fertility and Sterility. 2009;91:1215.
  19. Stewart EA (expert opinion). Mayo Clinic, Rochester, Minn. May 25, 2011.
DS00078 June 11, 2011

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