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Causes
By Mayo Clinic staffVasculitis occurs when your body attacks your blood vessels. It's not always clear why this happens, but an infection, some cancers, certain immune system disorders or an allergic reaction may serve as the trigger.
Blood vessels affected by vasculitis become inflamed, which can cause the layers of the blood vessel wall to thicken. This narrows the blood vessels, reducing the amount of blood — and therefore oxygen and vital nutrients — that reaches your body's tissues. In some cases, a blood clot may form in an affected blood vessel, obstructing blood flow. Sometimes instead of becoming narrower, a blood vessel may weaken and form a bulge (aneurysm), a potentially life-threatening condition.
Vasculitis with no known cause (primary vasculitis)
For many of its forms, the cause of vasculitis is unknown. These forms of vasculitis are called primary vasculitis.
Vasculitis that occurs due to another disease (secondary vasculitis)
Forms of vasculitis for which an underlying disease is the cause are called secondary vasculitis. Examples of causes of secondary vasculitis include:
- Infections. Some vasculitis occurs in response to an infection. For instance, most cases of cryoglobulinemia are the result of the hepatitis C virus infection, and the hepatitis B virus infection causes some cases of polyarteritis nodosa.
- Immune system diseases. Vasculitis can also occur as the result of some diseases of the immune system, such as rheumatoid arthritis, lupus and Sjogren's syndrome.
- Allergic reactions. Sometimes an allergic reaction to a medication may cause vasculitis.
- Blood cell cancers. Cancer that affects the blood cells, including leukemia and lymphoma, can cause vasculitis.
- What is vasculitis? National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/vas/vas_all.html. Accessed Aug. 26, 2009.
- Khasnis A, et al. Update on vasculitis. Journal of Allergy & Clinical Immunology. 2009;123:1226.
- Stone JH. The classification and epidemiology of systemic vasculitis. In: Firestein GS, et al. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa.: Elsevier; 2008. http://www.mdconsult.com/das/book/body/156758625-2/0/1807/0.html. Accessed Aug. 26, 2009.
- Vasculitis. American College of Rheumatology. http://www.rheumatology.org/public/factsheets/diseases_and_conditions/vasculitis.asp. Accessed Aug. 26, 2009.
- Questions to ask your doctor. Vasculitis Foundation. http://www.vasculitisfoundation.org/vasculitisquestionstoaskyourdoctor. Accessed Aug. 26, 2009.
- Chang-Miller A (expert opinion). Mayo Clinic, Scottsdale/Phoenix, Ariz. Sept. 2, 2009.
- Lee RW, et al. Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis. Drugs. 2008;68:747.
- Search of mycophenolate and vasculitis. ClinicalTrials.gov. http://www.clinicaltrials.gov/ct2/results?term=mycophenolate+and+vasculitis. Accessed Sept. 4, 2009.
