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Treatments and drugs
By Mayo Clinic staffSpecific treatment for vasculitis depends on your type of vasculitis, the severity of your case and your general health. Though some types of vasculitis are self-limiting and improve on their own, such as Henoch-Schonlein purpura, others require medications.
Medications used to treat vasculitis include:
- Steroids to control inflammation. Treatment for many types of vasculitis consists of doses of a corticosteroid drug, such as prednisone or methylprednisolone (Medrol), to control inflammation. Side effects of steroids can be severe, especially when taken over a long period of time. Side effects can include weight gain, diabetes and bone thinning (osteoporosis). You're likely to receive the lowest dose of steroids possible to control your disease.
- Medications to control the immune system. Severe cases of vasculitis or those that don't respond well to corticosteroids may need treatment with cytotoxic drugs that kill immune system cells responsible for causing inflammation. Cytotoxic drugs include azathioprine (Imuran) and cyclophosphamide (Cytoxan). Researchers have had some success using the immunosuppressant drug mycophenolate mofetil (Cellcept) to treat certain types of vasculitis, but are still testing the drug in clinical trials.
- What is vasculitis? National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/vas/vas_all.html. Accessed Aug. 26, 2009.
- Khasnis A, et al. Update on vasculitis. Journal of Allergy & Clinical Immunology. 2009;123:1226.
- Stone JH. The classification and epidemiology of systemic vasculitis. In: Firestein GS, et al. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa.: Elsevier; 2008. http://www.mdconsult.com/das/book/body/156758625-2/0/1807/0.html. Accessed Aug. 26, 2009.
- Vasculitis. American College of Rheumatology. http://www.rheumatology.org/public/factsheets/diseases_and_conditions/vasculitis.asp. Accessed Aug. 26, 2009.
- Questions to ask your doctor. Vasculitis Foundation. http://www.vasculitisfoundation.org/vasculitisquestionstoaskyourdoctor. Accessed Aug. 26, 2009.
- Chang-Miller A (expert opinion). Mayo Clinic, Scottsdale/Phoenix, Ariz. Sept. 2, 2009.
- Lee RW, et al. Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis. Drugs. 2008;68:747.
- Search of mycophenolate and vasculitis. ClinicalTrials.gov. http://www.clinicaltrials.gov/ct2/results?term=mycophenolate+and+vasculitis. Accessed Sept. 4, 2009.
