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Risk factors
By Mayo Clinic staffVentricular septal defect appears to run in families and sometimes occurs with other genetic problems, such as Down syndrome. If you already have a child with a heart defect, a genetic counselor can predict the approximate odds that your next child will have one.
Having the following conditions during pregnancy can increase your risk of having a baby with a heart defect.
- Rubella infection. Becoming infected with rubella (German measles) while pregnant can increase the risk of fetal heart defects. The rubella virus crosses the placenta and spreads through the fetus' circulatory system damaging blood vessels and organs, including the heart.
- Poorly controlled diabetes. Uncontrolled diabetes in the mother in turn affects the fetus' blood sugar, causing various damaging effects to the developing fetus.
- Drug or alcohol use or exposure to certain substances. Use of certain medications, alcohol or drugs or exposure to chemicals or radiation during pregnancy can harm the developing fetus.
- What are holes in the heart? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/holes/holes_whatare.html. Accessed Aug. 4, 2009.
- Ventricular septal defect (VSD). American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=11066. Accessed Aug. 4, 2009.
- Webb GD, et al. Congenital heart disease. In: Libby P, et al., eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-1-4160-4106-1..50064-9--cesec134&displayedEid=4-u1.0-B978-1-4160-4106-1..50064-9--cesec166&uniq=152762796&isbn=978-1-4160-4106-1#lpState=open&lpTab=contentsTab&content=4-u1.0-B978-1-4160-4106-1..50064-9%3Bfrom%3Dtoc%3Btype%3DbookPage%3Bisbn%3D978-1-4160-4106-1. Accessed Aug. 4, 2009.
- Dummer KB, et al. Pathophysiology and clinical features of isolated ventricular septal defects in infants and children. http://www.uptodate.com/home/index.html. Accessed Aug. 4, 2009.
- McMackin,CJ, et al. Ventricular septal defect. In: Ferri FF. Ferri's Clinical Advisor 2009. St. Louis, Mo.: Mosby; 2008. http://www.mdconsult.com/das/book/body/152762796-4/871305879/1701/628.html#4-u1.0-B978-0-323-04134-8..50025-2--subchapter8_13432. Accessed Aug. 4, 2009.
- Congenital heart defects. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4565. Accessed Aug. 4, 2009.
- Dummer KB, et al. Management of isolated ventricular septal defects in infants and children. http://www.uptodate.com/home/index.html. Accessed Aug. 4, 2009.
- Prevention of infective endocarditis: Guidelines from the American Heart Association. Circulation. 2007;116:1736.
- Genetic counseling for adults with congenital heart disease. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=11083. Accessed Aug. 20, 2009.
