Vitamin A (retinol)

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Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

Avoid in individuals with a known hypersensitivity/allergy to vitamin A.

Side Effects and Warnings

Vitamin A toxicity, or hypervitaminosis A, is rare in the general population. Vitamin A toxicity can occur with excessive amounts of vitamin A taken over short or long periods of time. Consequently, toxicity can be acute or chronic. An infant with acute toxicity can develop a bulging fontalle (the soft spot on the head) and symptoms similar to a brain tumor. Adults experience less specific symptoms such as headache, dizziness, fatigue, malaise, blurry vision, bone pain and swelling, nausea, and/or vomiting. Acute vitamin A toxicity may also lead to increased intracranial pressure, pruritus or itching, and bone problems. Severe toxicity can lead to eye damage, high levels of calcium, and liver damage. Persons with liver disease and high alcohol intake may be at risk for hepatotoxicity from vitamin A supplementation. Smokers who consume alcohol and beta-carotene may be at an increased risk for lung cancer or cardiovascular disease.

Vitamin A toxicity may lead to intrahepatic cholestasis, a condition where bile cannot flow from the liver into the intestines. Treatment with ursodeoxycholic acid has been shown to greatly improve the symptoms of cholestasis.

Pregnancy and Breastfeeding

Vitamin A should only be used within the recommended dietary allowance, because vitamin A excess, as well as deficiency, has been associated with birth defects. Excessive doses of vitamin A have been associated with central nervous system malformations.

Vitamin A is excreted in human breast milk. Benefits or dangers to nursing infants are not clearly established.

NS_patient-vitamina

Portions of this document last updated:

Sept. 1, 2009

THIS EVIDENCE-BASED MONOGRAPH WAS PREPARED BY
THE NATURAL STANDARD RESEARCH COLLABORATION
(www.naturalstandard.com)


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