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    Katherine Zeratsky, R.D., L.D.

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Question

Vitamin D toxicity: What if you get too much?

What is vitamin D toxicity, and should I worry about it since I take supplements?

Answer

from Katherine Zeratsky, R.D., L.D.

Vitamin D toxicity, also called hypervitaminosis D, is a potentially serious but treatable medical condition that occurs when you get too much vitamin D.

Vitamin D toxicity usually results from taking an excessive amount of vitamin D supplements — not from your diet or too much sun exposure. That's because your body regulates the amount of vitamin D produced from sun exposure, and even fortified foods don't contain large amounts of vitamin D.

Although vitamin D toxicity is rare even among people who take supplements, you may be at greater risk if you have health problems, such as liver or kidney conditions, or if you take thiazide-type diuretics. As always, make sure your doctor is aware of any vitamins or supplements you take.

The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), causing symptoms such as:

  • Vomiting
  • Polyuria (frequent urination)
  • Weight loss
  • Poor appetite
  • Constipation
  • Weakness
  • Heart rhythm abnormalities
  • Kidney stones

Treatment of vitamin D toxicity includes stopping vitamin D supplements and restricting calcium intake, as well as taking medication. In severe cases, hospitalization may be necessary.

Supplements can be a reasonable way to meet recommended levels — as long as you pay attention to how much you take. The recommended daily allowance of vitamin D is 600 international units (IU) for children and most adults. The recommendation for adults over age 70 is 800 IU daily. Above 4,000 IU a day the risk of adverse effects increases.

Finally, keep in mind that doctors may recommend higher does of vitamin D for a short time to treat an underlying medical problem such as vitamin D deficiency. However, such doses are given under the care of a doctor.

Next question
Too much vitamin C: Harmful?
References
  1. Leu JP, et al. Vitamin D toxicity: Caveat emptor. Endocrine Practice. 2008;14:1188.
  2. Hemmelgarn M. Shedding light on vitamin D. American Journal of Nursing. 2009;109:19.
  3. Lee JH, et al. Vitamin D deficiency: An important, common, and easily treatable cardiovascular risk factor? Journal of the American College of Cardiology. 2008;52:1949.
  4. Dietary Reference Intakes for calcium and vitamin D. Institute of Medicine. http://www.iom.edu/vitamind. Accessed May 25, 2011.
  5. Hathcock JN, et al. Risk assessment for vitamin D. American Journal of Clinical Nutrition. 2007;85:6.
  6. Brannon PM, et al. Overview of the conference "Vitamin D and Health in the 21st Century: An Update." American Journal of Clinical Nutrition. 2008;88(suppl):483S.
  7. Vitamin D. The Merck Manuals: The Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec01/ch004/ch004k.html. Accessed May 25, 2011.
  8. Hensrud DD (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 9, 2010.
  9. Dietary Guidelines for Americans, 2010. U.S. Department of Health and Human Services. http://www.cnpp.usda.gov/DGAs2010-PolicyDocument.htm. Accessed May 25, 2011.
AN02008 Aug. 20, 2011

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