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Causes
By Mayo Clinic staffThe cause of Wegener's granulomatosis is unknown, but it appears to develop as a result of an initial inflammation-causing event that triggers an abnormal reaction from your immune system. The combination of these events can lead to inflamed, constricted blood vessels and harmful inflammatory tissue masses (granulomas). Scientists speculate that the triggering event may be an infection, but no specific infection has been identified as the cause.
- Wegener's granulomatosis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec04/ch033/ch033k.html#sec04-ch033-ch033k-362. Accessed July 26, 2010.
- Wegener's granulomatosis. National Institute of Allergy and Infectious Diseases. http://www.niaid.nih.gov/topics/wegeners/Pages/Default.aspx. Accessed July 26, 2010.
- Hellmann DB, et al. Musculoskeletal and immunologic disorders. In: McPhee SJ, et al. Current Medical Diagnosis and Treatment 2010. 49th ed. New York, N.Y.: McGraw Hill; 2010. http://www.accessmedicine.com/content.aspx?aID=10083. Accessed July 30, 2010.
- Langford CA, et al. The vasculitis syndromes. In: Fauci AS, et al. Harrison's Principles of Internal Medicine. 17th ed. New York, N.Y.: McGraw Hill; 2008. http://www.accessmedicine.com/content.aspx?aID=2859426. Accessed July 30, 2010.
- King TE, et al. Clinical manifestations and diagnosis of Wegener's granulomatosis and microscopic polyangiitis. http://www.uptodate.com/home/index.html. Accessed July 26, 2010.
- Stone JH, et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. New England Journal of Medicine. 2010;363:221.
- Turnball J, et al. Adverse effects of therapy for ANCA-associated vasculitis. Best Practice and Research Clinical Rheumatology. 2009;23:391.
- Rosenow E (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 3, 2010.
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