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Complications
By Mayo Clinic staff
The lining of your small intestine has fine hair-like projections (villi) that help your body absorb nutrients. Whipple's disease damages the villi, impairing nutrient absorption. Nutritional deficiencies are common in people with Whipple's disease and can lead to fatigue, weakness, weight loss and joint pain.
Whipple's disease is a progressive and potentially fatal disease. Although the infection is rare, associated deaths continue to be reported, due in large part to late diagnoses and delayed treatment. Death often is caused by the spread of the infection to the central nervous system, which can cause irreversible damage.
- Whipple's disease. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/whipple/. Accessed April 20, 2010.
- Schneider T, et al. Whipple's disease: New aspects of pathogenesis and treatment. The Lancet. 2008;8:179.
- Infectious enterocolitis. In: Kumar V, et al. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/198838576-5/991412257/2060/201.html#4-u1.0-B978-1-4377-0792-2..50022-5--cesec139_1852. Accessed April 20, 2010.
- Apstein M, et al. Whipple's disease. http://www.uptodate.com/home/index.html. Accessed April 20, 2010.
- Marth T, et al. Whipple's disease. In: Mandell GL, et al. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 76th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier: 2009. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-0-443-06839-3..00101-6--s0025&uniq=198838576&isbn=978-0-443-06839-3&sid=991410994#lpState=open&lpTab=contentsTab&content=4-u1.0-B978-0-443-06839-3..00101-6--s0030%3Bfrom%3Dtoc%3Btype%3DbookPage%3Bisbn%3D978-0-443-06839-3. Accessed April 30, 2010.
- Steckelberg JM (expert opinion). Mayo Clinic, Rochester, Minn. April 30, 2010.
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