A single copy of this article may be reprinted for personal, noncommercial use only.
Wrinkle creams: Your guide to younger looking skinBy Mayo Clinic staff
Original Article: http://www.mayoclinic.com/health/wrinkle-creams/SN00010
Lifestyle and home remedies (1)
- Skin care: 5 tips for healthy skin
- Best sunscreen: Understand sunscreen options
Wrinkle creams: Your guide to younger looking skin
Do over-the-counter wrinkle creams really reduce the appearance of fine lines and wrinkles? The answer depends on many factors.By Mayo Clinic staff
Many wrinkle creams and lotions sold in department stores, in drugstores and on the Internet promise to reduce wrinkles and prevent or reverse damage caused by the sun.
Do they work? Research suggests that some wrinkle creams contain ingredients that may improve the appearance of wrinkles. But many of these ingredients haven't undergone scientific research to prove this benefit.
If you're looking for a face-lift in a bottle, you probably won't find it in over-the-counter (nonprescription) wrinkle creams. But they may slightly improve the appearance of your skin, depending on how long you use the product and the amount and type of the active ingredient in the wrinkle cream.
Common ingredients in anti-wrinkle creams
The effectiveness of anti-wrinkle creams depends in part on the active ingredient or ingredients. Here are some common ingredients that may result in slight to modest improvement in the appearance of wrinkles.
- Retinol. Retinol is a vitamin A compound, the first antioxidant to be widely used in nonprescription wrinkle creams. Antioxidants are substances that neutralize free radicals — unstable oxygen molecules that break down skin cells and cause wrinkles. Retinol is less potent than the vitamin A derivative tretinoin, a topical treatment approved by the Food and Drug Administration (FDA) for treating wrinkles. Tretinoin is available only by prescription. Avoid vitamin A derivatives if you are pregnant or may become pregnant, because they may increase the risk of birth defects.
- Hydroxy acids. Alpha hydroxy acids, beta hydroxy acids and poly hydroxy acids are synthetic versions of acids derived from sugar-containing fruits. These acids are exfoliants — substances that remove the upper layer of old, dead skin and stimulate the growth of smooth, evenly pigmented new skin. Because hydroxy acids increase your susceptibility to sun damage, always wear sunscreen during use and for at least one week afterward.
- Coenzyme Q10. Coenzyme Q10 is a nutrient that helps regulate energy production in cells. Some studies have shown reduction in fine wrinkles around the eyes with no side effects. Other studies show that application before sun exposure protects against sun damage.
- Copper peptides. Copper is a trace element found in every cell. In products applied to the skin, it's combined with small protein fragments called peptides. Copper peptides enhance wound healing. They also stimulate production of collagen and may enhance the action of antioxidants.
- Kinetin. As a plant growth factor, kinetin may improve the appearance of wrinkles and uneven pigmentation with minimal irritation. It's unclear how it works, but it may help reduce wrinkles by helping skin retain moisture and by stimulating the production of collagen. It may also be a potent antioxidant.
- Tea extracts. Green, black and oolong tea contain compounds with antioxidant and anti-inflammatory properties. Green tea extracts are the ones most commonly found in wrinkle creams.
No guarantees: Assessing safety and effectiveness
The FDA classifies creams and lotions as cosmetics, which are defined as having no medical value. So the FDA regulates them less strictly than it does drugs. This means that products don't undergo the same rigorous testing for safety and effectiveness that topically applied medications undergo before approval to go on the market. Regarding this category of creams and lotions, the FDA's main concern is safety, not effectiveness.
The FDA does step in, however, when advertisements portray cosmetics as drugs or when cosmetics contain ingredients that may pose a potential health hazard to consumers. For example, in 2002 the FDA ordered manufacturers of products containing alpha hydroxy acids to include a warning label stating that the acids may increase the risk of sunburn.
Because the FDA doesn't evaluate cosmetic products for effectiveness, there's no guarantee that any over-the-counter product will reduce your wrinkles.
Consider these points when judging the merits of using a wrinkle cream:
- Cost. Cost has no relationship to effectiveness. A wrinkle cream that's more costly may not be more effective than a less-costly product.
- Latest research. Research suggests that certain ingredients may improve the appearance of wrinkles. However, most anti-wrinkle creams haven't been subjected to the comprehensive, objective research required to prove this benefit.
- Lower doses. Nonprescription wrinkle creams contain lower concentrations of active ingredients than do prescription creams. So results, if any, are limited and usually short-lived.
- Daily use. You'll likely need to use the wrinkle cream once or twice a day for many weeks before noticing any improvements. And once you discontinue using the product, your skin is likely to return to its original appearance.
- Side effects. Some products may cause skin irritation, rashes, burning or redness. Be sure to read and follow the product instructions to limit possible side effects.
- Individual differences. Just because your friend swears by a product doesn't mean it will work for you. People have different skin types. No one product works the same for everyone.
Your anti-wrinkle regimen
An anti-wrinkle cream may lessen the appearance of your wrinkles, depending on how often you use it, the type and amount of active ingredient in the wrinkle cream, and the extent of the wrinkles you want to treat.
But if you want to take the guesswork out of your skin care regimen, try these more reliable ways to improve and maintain your skin's youthful appearance.
- Protect your skin from the sun. Exposure to ultraviolet (UV) light speeds up the natural aging process of your skin, causing wrinkles and rough, blotchy skin. In fact, sun exposure is the No. 1 reason for signs of aging in the skin, including uneven pigmentation. Protect your skin — and prevent future wrinkles — by limiting the time you spend in the sun and always wearing protective clothing and hats. Also, use sunscreen on exposed skin when outdoors, even in winter.
- Choose products with built-in sunscreen. When selecting skin care products, choose those with a built-in sun protection factor (SPF) of at least 15. Also, be sure to select products that are broad spectrum, meaning they block both UVA and UVB rays.
- Use moisturizers. Dry skin turns plump skin cells into shriveled ones, creating fine lines and wrinkles long before you're due. Though moisturizers can't prevent wrinkles, they can temporarily mask tiny lines and creases.
- Don't smoke. Smoking causes narrowing of the blood vessels in the outermost layers of your skin. It also damages collagen and elastin — fibers that give your skin its strength and elasticity. As a result, skin begins to sag and wrinkle prematurely.
- Eat a healthy diet. There is some evidence that certain vitamins in your diet help protect your skin, particularly vitamins A, C, B3 and E. More study is needed on the role of nutrition.
If you're concerned about the appearance of your skin, see your dermatologist. He or she can help you create a personalized skin care plan by assessing your skin type, evaluating your skin's condition and recommending products likely to be effective. If you're looking for more dramatic results, a dermatologist can recommend medical treatments for wrinkles, including prescription creams, botulinum toxin (Botox) injections or skin-resurfacing techniques.
- 10 tips: Selecting age-fighting topicals. American Academy of Dermatology. http://www.skincarephysicians.com/agingskinnet/age_fighting_selecting.html. Accessed Aug. 5, 2010.
- Stern RS. Treatment of photoaging. New England Journal of Medicine. 2004;350:1526.
- Kim H, et al. Improvement in skin wrinkles from the use of photostable retinyl retinoate: A randomized controlled trial. British Journal of Dermatology. 2010:162:497.
- Watson REB, et al. Repair of photoaged dermal matrix by topical application of a cosmetic "antiageing" product. British Journal of Dermatology. 2008:158:472.
- Cosmeceutical facts and your skin. American Academy of Dermatology. http://www.aad.org/public/publications/pamphlets/general_cosmeceutical.html. Accessed Aug. 5, 2010.
- Labeling for cosmetics containing alpha hydroxy acids. U.S. Food and Drug Administration. www.fda.gov/Cosmetics/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/ucm090816.htm. Accessed Aug. 5, 2010.
- Zussman J, et al. Vitamins and photoaging: Do scientific data support their use? Journal of the American Academy of Dermatology. 2010;63(3):507.
- 10 tips: Getting the best results from age-fighting topicals. American Academy of Dermatology. http://www.skincarephysicians.com/agingskinnet/age_fighting_results.html. Accessed Aug. 5, 2010.
- Aging hair/skin problems: Wrinkles. American Academy of Dermatology. http://www.skincarephysicians.com/agingskinnet/wrinkles.html. Accessed Aug. 6, 2010.