Zollinger-Ellison syndrome

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Introduction Signs and symptoms Causes

When to seek medical advice Screening and diagnosis Treatment

Introduction

Zollinger-Ellison syndrome is a complex condition in which one or more tumors form in the pancreas or in the upper part of the small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes excessive production of acid by your stomach. The excess acid, in turn, leads to peptic ulcers.

The ulcers that occur as part of Zollinger-Ellison syndrome are often numerous, tend to occur in unusual areas of your stomach or intestine and are more resistant to treatment than other ulcers are. They are also likely to return after being treated.

Zollinger-Ellison syndrome is rare, affecting approximately one in 1 million people. In the United States, less than 1 percent of duodenal ulcers result from Zollinger-Ellison. The disease may occur at any time, but the average age at diagnosis is 50.

Most often, treatment for Zollinger-Ellison syndrome consists of medications to reduce acid and heal the ulcers. Surgery to remove the tumors may be an option for some people with Zollinger-Ellison.

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Signs and symptoms