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Symptoms
By Mayo Clinic staffZollinger-Ellison syndrome causes signs and symptoms similar to those of a peptic ulcer. These may include:
- Abdominal pain
- Diarrhea
- Burning, aching, gnawing or discomfort in your upper abdomen
- Heartburn
- Nausea and vomiting
- Weakness
- Bleeding in your digestive tract
- Unintended weight loss
- Decreased appetite
- Anemia
When to see a doctor
See your doctor if you have a persistent, burning, aching or gnawing pain in your upper abdomen, especially if you've also been experiencing nausea, vomiting and diarrhea.
Tell your doctor if you've used over-the-counter acid-reducing medications such as omeprazole (Prilosec), cimetidine (Tagamet), famotidine (Pepcid) or ranitidine (Zantac) for long periods of time. These medications may mask your symptoms, which could delay your diagnosis. If you have Zollinger-Ellison syndrome, early detection and treatment are important.
- Zollinger-Ellison syndrome. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/zollinger. Accessed May 5, 2010.
- How is cancer of the pancreas diagnosed? American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_3X_How_is_pancreatic_cancer_diagnosed_34.asp?sitearea=. Accessed May 5, 2010.
- Goldfinger SE. Clinical manifestations and diagnosis of Zollinger-Ellison syndrome (gastrinoma). http://www.uptodate.com/home/index.html. Accessed May 8, 2010.
- Goldfinger SE. Management and prognosis of Zollinger-Ellison syndrome (gastrinoma). http://www.uptodate.com/home/index.html. Accessed May 8, 2010.
- Morrow EH, et al. Surgical management of Zollinger-Ellison syndrome; State of the art. Surgical Clinics of North America. 2009;89:1091.
- Wilcox CM, et al. Treatment strategies for Zollinger-Ellison syndrome. Expert Opinion on Pharmacotherapy. 2009;10:1145.
- FDA Drug Safety Communication: Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm213206.htm. Accessed May 26, 2010.
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