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Definition
By Mayo Clinic staffZollinger-Ellison syndrome is a complex condition in which one or more tumors form in your pancreas, the upper part of your small intestine (duodenum) or the lymph nodes adjacent to your pancreas. These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid. The excess acid, in turn, leads to peptic ulcers.
Zollinger-Ellison syndrome, also called ZES, is rare. The disease may occur at any time in life, but people are usually diagnosed between ages 20 and 50. It's slightly more common in men.
Treatment for Zollinger-Ellison syndrome most often consists of medications to reduce stomach acid and heal the ulcers. Surgery to remove the tumors may be an option for some people with Zollinger-Ellison syndrome.
- Zollinger-Ellison syndrome. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/zollinger. Accessed May 5, 2010.
- How is cancer of the pancreas diagnosed? American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_3X_How_is_pancreatic_cancer_diagnosed_34.asp?sitearea=. Accessed May 5, 2010.
- Goldfinger SE. Clinical manifestations and diagnosis of Zollinger-Ellison syndrome (gastrinoma). http://www.uptodate.com/home/index.html. Accessed May 8, 2010.
- Goldfinger SE. Management and prognosis of Zollinger-Ellison syndrome (gastrinoma). http://www.uptodate.com/home/index.html. Accessed May 8, 2010.
- Morrow EH, et al. Surgical management of Zollinger-Ellison syndrome; State of the art. Surgical Clinics of North America. 2009;89:1091.
- Wilcox CM, et al. Treatment strategies for Zollinger-Ellison syndrome. Expert Opinion on Pharmacotherapy. 2009;10:1145.
- FDA Drug Safety Communication: Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm213206.htm. Accessed May 26, 2010.
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