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Caffeine: How much is too much?

By Mayo Clinic staff

If you rely on caffeine to wake you up and keep you going, you aren't alone. Caffeine stimulates the central nervous system, alleviating fatigue and increasing wakefulness.

When to consider cutting back

For most people, moderate doses of caffeine — 200 to 300 milligrams (mg), or about two to four cups of brewed coffee a day — aren't harmful. But some circumstances may warrant limiting or even ending your caffeine routine. Read on to see if any of these apply to you.

'Grande' is your middle name

Though moderate caffeine intake isn't likely to cause harm, too much can noticeably affect your health. Heavy daily caffeine use — more than 500 to 600 mg a day, or about four to seven cups of coffee — can cause:

  • Insomnia
  • Nervousness
  • Restlessness
  • Irritability
  • Nausea or other gastrointestinal problems
  • Fast or irregular heartbeat
  • Muscle tremors
  • Headaches
  • Anxiety

Even a little makes you jittery

Some people are more sensitive to caffeine than are others. If you're susceptible to the effects of caffeine, just small amounts — even one cup of coffee or tea — may prompt unwanted effects, such as anxiety, restlessness, irritability and sleep problems. How you react to caffeine may be determined in part by how much caffeine you're used to drinking. So, people who don't regularly consume caffeine tend to be more sensitive to its negative effects. Other factors may include body mass, age, smoking habits, drug or hormone use, stress and health conditions such as anxiety disorders. Sex may even play a role: Research suggests that men are more susceptible to caffeine than are women.

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References
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  2. Nawrot P, et al. Effects of caffeine on human health. Food Additives and Contaminants 2003;20:1.
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  5. Attwood A, et al. Differential responsiveness to caffeine and perceived effects of caffeine in moderate and high regular caffeine consumers. Psychopharmacology. 2007;190:469.
  6. Adan A, et al. Early effects of caffeinated and decaffeinated coffee on subjective state and gender differences. Progress in Neuropsychopharmacology and Biological Psychiatry. 2008;32:1698.
  7. Sleep problems? Watch the caffeine. National Sleep Foundation. http://www.sleepfoundation.org/PressArchives/caffcalc.cfm. Accessed Jan. 31, 2005.
  8. Ciprofloxacin. Micromedex Healthcare Series. http://www.thomsonhc.com. Accessed Jan. 13, 2009.
  9. Norfloxacin. Micromedex Healthcare Series. http://www.thomsonhc.com. Accessed Jan. 13, 2009.
  10. Xanthine derivatives. Facts and Comparisons, 2009. http://online.factsandcomparisons.com/MonoDisp.aspx?id=635625&book=DFC. Accessed Jan. 13, 2009.
  11. Ephedra. National Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Jan. 13, 2009.
  12. Juliano LM, et al. A critical review of caffeine withdrawal: Empirical validation of symptoms and signs, incidence, severity and associated features. Psychopharmacology. 2004;176:1.
  13. Buss LK (expert opinion). Mayo Clinic, Rochester, Minn., Jan. 13, 2009.

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March 24, 2009

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