In vitro fertilization (IVF) is a treatment for infertility or genetic problems. If IVF is performed to treat infertility, you and your partner might be able to try less invasive treatment options before attempting IVF, including fertility drugs to increase production of eggs or intrauterine insemination — a procedure in which sperm are placed directly in your uterus near the time of ovulation.
Sometimes, IVF is offered as a primary treatment for infertility in women over age 40. IVF can also be done if you have certain health conditions. For example, IVF may be an option if you or your partner has:
- Fallopian tube damage or blockage. Fallopian tube damage or blockage makes it difficult for an egg to be fertilized or for an embryo to travel to the uterus.
- Ovulation disorders. If ovulation is infrequent or absent, fewer eggs are available for fertilization.
- Premature ovarian failure. Premature ovarian failure is the loss of normal ovarian function before age 40. If your ovaries fail, they don't produce normal amounts of the hormone estrogen or have eggs to release regularly.
- Endometriosis. Endometriosis occurs when the uterine tissue implants and grows outside of the uterus — often affecting the function of the ovaries, uterus and fallopian tubes.
- Uterine fibroids. Fibroids are benign tumors in the wall of the uterus and are common in women in their 30s and 40s. Fibroids can interfere with implantation of the fertilized egg.
- Previous tubal sterilization or removal. If you've had tubal ligation — a type of sterilization in which your fallopian tubes are cut or blocked to permanently prevent pregnancy — and want to conceive, IVF may be an alternative to tubal ligation reversal.
- Impaired sperm production or function. Below-average sperm concentration, weak movement of sperm (poor mobility), or abnormalities in sperm size and shape can make it difficult for sperm to fertilize an egg. If semen abnormalities are found, your partner might need to see a specialist to determine if there are correctable problems or underlying health concerns.
- Unexplained infertility. Unexplained infertility means no cause of infertility has been found despite evaluation for common causes.
- A genetic disorder. If you or your partner is at risk of passing on a genetic disorder to your child, you may be candidates for preimplantation genetic diagnosis — a procedure that involves IVF. After the eggs are harvested and fertilized, they're screened for certain genetic problems, although not all genetic problems can be found. Embryos that don't contain identified problems can be transferred to the uterus.
Fertility preservation for cancer or other health conditions. If you're about to start cancer treatment — such as radiation or chemotherapy — that could harm your fertility, IVF for fertility preservation may be an option. Women can have eggs harvested from their ovaries and frozen in an unfertilized state for later use. Or the eggs can be fertilized and frozen as embryos for future use.
Women who don't have a functional uterus or for whom pregnancy poses a serious health risk might choose IVF using another person to carry the pregnancy (gestational carrier). In this case, the woman's eggs are fertilized with sperm, but the resulting embryos are placed in the gestational carrier's uterus.
June 16, 2016
- Medications for inducing ovulation: A guide for patients. American Society for Reproductive Medicine. http://www.reproductivefacts.org/BOOKLET_Medications_for_Inducing_Ovulation/. Accessed March 30, 2016.
- Paulson R. In vitro fertilization. http://www.uptodate.com/home. Accessed March 30, 2016.
- Paulson R. Pregnancy outcome after assisted reproductive technology. http://www.uptodate.com/home. Accessed March 31, 2016.
- ART: Step-by-step guide. Society for Assisted Reproductive Technology. http://www.sart.org/ART_Step-by-Step_Guide/. Accessed March 31, 2016.
- Treating infertility. American College of Obstetricians and Gynecologists. http://www.acog.org/Patients/FAQs/Treating-Infertility. Accessed March 31, 2016.
- Evaluating infertility. American College of Obstetricians and Gynecologists. http://www.acog.org/Patients/FAQs/Evaluating-Infertility. Accessed March 31, 2016.
- Infertility fact sheet. Office On Women's Health. http://www.womenshealth.gov/publications/our-publications/fact-sheet/infertility.html. Accessed March 31, 2016.
- Risks of in vitro fertilization (IVF). American Society for Reproductive Medicine. http://www.womenshealth.gov/publications/our-publications/fact-sheet/infertility.html. Accessed March 31, 2016.
- 2013 Assisted reproductive technology fertility clinic success rates report. Centers for Disease Control and Prevention. http://www.cdc.gov/art/reports/2013/fertility-clinic.html. Accessed March 31, 2016.
- Infertility FAQs. Centers for Disease Control and Prevention. http://www.cdc.gov/reproductivehealth/Infertility/. Accessed March 31, 2016.
- Assisted reproductive technologies: A guide for patients. American Society for Reproductive Medicine. https://www.asrm.org/BOOKLET_Assisted_Reproductive_Technologies/. Accessed March 31, 2016.
- Coddington III CC (expert opinion). Mayo Clinic, Rochester, Minn. April 4, 2016.
- Intrauterine insemination. American Society for Reproductive Medicine. http://www.asrm.org/FACTSHEET_Intrauterine_Insemination_IUI/. Accessed March 30, 2016.
- Anchan RM, et al. Surrogate pregnancy. https://www.uptodate.com/home. Accessed March 31, 2016.
In vitro fertilization (IVF)