Overview

A pancreas transplant is a surgical procedure to place a healthy pancreas from a deceased donor into a person whose pancreas no longer functions properly.

Your pancreas is an organ that lies behind the lower part of your stomach. One of its main functions is to make insulin, a hormone that regulates the absorption of sugar (glucose) into your cells.

If your pancreas doesn't make enough insulin, blood sugar levels can rise to unhealthy levels, resulting in type 1 diabetes.

Most pancreas transplants are done to treat type 1 diabetes. A pancreas transplant offers a potential cure for this condition. But it is typically reserved for those with serious diabetes complications, because the side effects of a pancreas transplant are significant.

In some cases, pancreas transplants may also treat type 2 diabetes. Rarely, pancreas transplants may be used in the treatment of pancreatic, bile duct or other cancers.

A pancreas transplant is often done in conjunction with a kidney transplant in people whose kidneys have been damaged by diabetes.

Mayo Clinic's approach

June 24, 2016
References
  1. Klein CL, et al. Patient selection for and immunologic issues relating to kidney-pancreas transplantation in diabetes mellitus. http://www.uptodate.com/home. Accessed March 21, 2016.
  2. Klein C, et al. Benefits and complications associated with kidney-pancreas transplantation in diabetes mellitus. http://www.uptodate.com/home. Accessed March 21, 2016.
  3. Pancreas transplantation. American Diabetes Association. http://www.diabetes.org/living-with-diabetes/treatment-and-care/transplantation/pancreas-transplantation.html. Accessed March 21, 2016.
  4. Robertson RP. Pancreas and islet transplantation in diabetes mellitus. http://www.uptodate.com/home. Accessed March 21, 2016.
  5. Health after transplantation. American Society of Transplantation. http://www.healthytransplant.com/health_maintenance/health_after_transplantation.aspx Accessed March 22, 2016.
  6. Preparing for the transplant. American Society of Transplantation. http://www.healthytransplant.com/health_maintenance/preparing_for_transplant.aspx. Accessed March 22, 2016.
  7. Kidney-pancreas transplant. National Kidney Foundation. http://www.kidney.org/atoz/content/kidpantx.cfm. Accessed March 22, 2016.
  8. Scientific Registry of Transplant Recipients 2012 Annual Data Report: Pancreas. Health Resources and Services Administration. http://srtr.transplant.hrsa.gov/annual_reports/2012. Accessed April 12, 2016.
  9. Chakkera HA (expert opinion). Mayo Clinic, Phoenix, Arizona. April 12, 2016.
  10. Side effects. UNOS Transplant Living. http://transplantliving.org/after-the-transplant/medications/side-effects/. Accessed March 22, 2016.
  11. Pancreas transplant. National Kidney Foundation. https://www.kidney.org/atoz/content/pancreastx. Accessed March 22, 2016.
  12. Heilman RL, et al. Immunosuppression in simultaneous pancreas-kidney transplantation. Drugs. 2010;70:793.
  13. Kandaswamy R, et al. Pancreas. American Journal of Transplantation. 2016;16(suppl 2):47.
  14. Pancreas. Organ Procurement and Transplantation Network. https://optn.transplant.hrsa.gov/data/organ-datasource/pancreas/. Accessed March 23, 2016.
  15. Barbara Woodward Lips Patient Education Center. Pancreas transplant. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
  16. Pancreas. PubMed Health. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0015631/. Accessed April 7, 2016.
  17. Guidance for industry: Considerations for allogeneic pancreatic islet cell products. U.S. Food and Drug Administration. http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/ucm182440.htm. Accessed March 28, 2016.
  18. Pancreatic islet transplantation. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/Diabetes/pancreatic-islet-transplantation/Pages/index.aspx. Accessed March 28, 2016.
  19. Kudva YC, et al. Comprehensive immune monitoring reveals profound immunological changes in pancreas after kidney (PAK) transplant recipients. Human Immunology. 2013;74:738.
  20. Reddy KS, et al. Alemtuzumab with rapid steroid taper in simultaneous kidney and pancreas transplantation: Comparison to induction with antithymocyte globulin. Transplantation Proceedings. 2010;42:2006.
  21. Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. April 6, 2016.