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Harmeet Malhi, M.B.B.S.

  1. Transplant Hepatologist
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Publications

  1. de Hoyos-Vega JM, Gonzalez-Suarez AM, Cedillo-Alcantar DF, Stybayeva G, Matveyenko A, Malhi H, Garcia-Cordero JL, Revzin A. Microfluidic 3D hepatic cultures integrated with a droplet-based bioanalysis unit. Biosens Bioelectron. 2024 Mar 15; 248:115896 Epub 2023 Nov 30
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  2. Wong CC, Tapper EB, Malhi H, Gores GJ. Manuscript best practices: Takeaways from a community conversation. Hepatology. 2024 Mar 11 [Epub ahead of print]
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  3. Parthasarathy G, Mauer AS, Golla N, Daniel PV, Kim LH, Sidhu GS, Marek GW 3rd, Loeuillard E, Krishnan A, Lee HSK, Pavelko KD, Charlton M, Hirsova P, Ilyas SI, Malhi H. Macrophage RAGE activation is proinflammatory in NASH. JCI Insight. 2024 Feb 8; 9 (3) Epub 2024 Feb 08
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  4. Lee S, Verkhoturov DS, Eller MJ, Verkhoturov SV, Shaw MA, Gwon K, Kim Y, Lucien F, Malhi H, Revzin A, Schweikert EA. Nanoprojectile Secondary Ion Mass Spectrometry Enables Multiplexed Analysis of Individual Hepatic Extracellular Vesicles. ACS Nano. 2023 Dec 12; 17 (23):23584-23594 Epub 2023 Nov 30
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  5. Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals. Hepatology. 2023 Dec 1; 78 (6):1680-1681 Epub 2023 Nov 09
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  6. Malhi H, Gores GJ. Introducing the Editorial Fellow and the Fellows' Corner. Hepatology. 2023 Dec 1; 78 (6):1677 Epub 2023 Nov 16
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  7. Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals. Clin Liver Dis (Hoboken). 2023 Dec; 22 (6):193-194 Epub 2023 Nov 09
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  8. Venkatesan N, Doskey LC, Malhi H. The Role of Endoplasmic Reticulum in Lipotoxicity during Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Pathogenesis. Am J Pathol. 2023 Dec; 193 (12):1887-1899 Epub 2023 Sept 07
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  9. Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals. Liver Transpl. 2023 Dec 1; 29 (12):1262-1263 Epub 2023 Nov 09
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  10. Avitabile E, Diaz A, Montironi C, Perez-Guasch M, Gratacos-Gines J, Hernandez-Evole H, Moreira RK, Sehrawat TS, Malhi H, Olivas P, Hernandez-Gea V, Bataller R, Shah VH, Kamath PS, Gines P, Pose E. Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated Hepatitis. Clin Gastroenterol Hepatol. 2023 Nov; 21 (12):3080-3088.e9 Epub 2023 Mar 31
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  11. Avitabile E, Diaz A, Montironi C, Perez-Guasch M, Gratacos-Gines J, Hernandez-Evole H, Moreira RK, Sehrawat TS, Malhi H, Olivas P, Hernandez-Gea V, Bataller R, Shah VH, Kamath PS, Gines P, Pose E. Adding inflammatory markers and refining national institute on alcohol abuse and alcoholism criteria improve diagnostic accuracy for alcohol-associated hepatitis. Clinical Gastroenterology and Hepatology. 2023 Nov; 21 (12):3080-8.e9
  12. Wu T, Hagiwara M, Gnass E, Barman H, Sasson D, Treem W, Ren K, Marins EG, Karki C, Malhi H. Liver disease progression in patients with alpha-1 antitrypsin deficiency and protease inhibitor ZZ genotype with or without lung disease. Aliment Pharmacol Ther. 2023 Nov; 58 (10):1075-1085 Epub 2023 Sept 17
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  13. Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals. Hepatol Commun. 2023 Nov 1; 7 (11) Epub 2023 Nov 09
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  14. Eskridge W, Cryer DR, Schattenberg JM, Gastaldelli A, Malhi H, Allen AM, Noureddin M, Sanyal AJ. Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis: The Patient and Physician Perspective. J Clin Med. 2023 Sep 26; 12 (19) Epub 2023 Sept 26
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  15. Malhi H, Shah V, Gores GJ. Thematic reviews: The future of hepatology. Hepatology 2023 Aug 1; 78 (2):388 Epub 2023 Apr 19
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  16. Muturi HT, Ghadieh HE, Abdolahipour R, Stankus HL, Belew GD, Liu JK, Jahromi MS, Lee AD, Singer BB, Angeli-Pahim I, Sehrawat TS, Malhi H, Verhulst S, van Grunsven LA, Zarrinpar A, Duarte S, Najjar SM. Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. Metabolism. 2023 Jul; 144:155562 Epub 2023 Apr 21
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  17. Parthasarathy G, Hirsova P, Kostallari E, Sidhu GS, Ibrahim SH, Malhi H. Extracellular Vesicles in Hepatobiliary Health and Disease. Compr Physiol. 2023 Jun 26; 13 (3):4631-4658 Epub 2023 June 26
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  18. Daniel PV, Malhi H. Foreseeing Alcohol-Associated Liver Disease through Proteomic Biomarkers. Clin Chem 2023 Apr 28; 69 (5):438-441
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  19. Malhi H, Gores GJ. Letters to the Editor: defining utility and pertinence. Hepatology. 2023 Apr 1; 77 (4):1069-1070 Epub 2023 Feb 03
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  20. Singal AK, Shah VH, Malhi H. Emerging targets for therapy in ALD: Lessons from NASH. Hepatology. 2023 Mar 21 [Epub ahead of print]
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  21. Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G, Kaufman RJ, Malhi H, Ren J. Endoplasmic reticulum stress in liver diseases. Hepatology. 2023 Feb 1; 77 (2):619-639 Epub 2022 May 24
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  22. Liao CY, Barrow F, Venkatesan N, Nakao Y, Mauer AS, Fredrickson G, Song MJ, Sehrawat TS, Dasgupta D, Graham RP, Revelo XS, Malhi H. Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis. Front Immunol. 2023; 14:1130184 Epub 2023 Apr 21
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  23. Venkatesan N, Doskey LC, Malhi H. The role of endoplasmic reticulum in lipotoxicity during metabolic dysfunction -- associated steatotic Liver Disease (MASLD) Pathogenesis. American Journal of Pathology. 2023; 193 (12):1887-99
  24. Tang H, Li J, Zinker B, Boehm S, Mauer A, Rex-Rabe S, Glaser KJ, Fronheiser M, Bradstreet T, Nakao Y, Petrone T, Pena A, Villano M, Chow P, Malhi H, Charles ED, Hayes W, Ehman RL, Du S, Yin M. Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis. J Magn Reson Imaging. 2022 Sep; 56 (3):712-724 Epub 2022 Jan 29
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  25. Parthasarathy G, Malhi H. Assessment of Lipotoxic Endoplasmic Reticulum (ER) Stress in Nonalcoholic Steatohepatitis (NASH). Methods Mol Biol. 2022; 2455:243-254
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  26. Lee S, Crulhas BP, Suvakov S, Verkhoturov SV, Verkhoturov DS, Eller MJ, Malhi H, Garovic VD, Schweikert EA, Stybayeva G, Revzin A. Nanoparticle-Enabled Multiplexed Electrochemical Immunoassay for Detection of Surface Proteins on Extracellular Vesicles. ACS Appl Mater Interfaces. 2021 Nov 10; 13 (44):52321-52332 Epub 2021 Oct 28
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  27. Watt KD, Heimbach JK, Rizk M, Jaruvongvanich P, Sanchez W, Port J, Venkatesh SK, Bamlet H, Tiedtke K, Malhi H, Acosta Cardenas A, Grothe K, Clark M, Mundi MS, Abu Dayyeh BK. Efficacy and Safety of Endoscopic Balloon Placement for Weight Loss in Patients With Cirrhosis Awaiting Liver Transplantation. Liver Transpl. 2021 Sep; 27 (9):1239-1247 Epub 2021 July 26
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  28. Nakao Y, Amrollahi P, Parthasarathy G, Mauer AS, Sehrawat TS, Vanderboom P, Nair KS, Nakao K, Allen AM, Hu TY, Malhi H. Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery. Nanomedicine. 2021 Aug; 36:102430 Epub 2021 June 24
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  29. Parthasarathy G, Malhi H. Macrophage Heterogeneity in NASH: More Than Just Nomenclature. Hepatology 2021 Jul; 74 (1):515-518 Epub 2021 May 22
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  30. Xue F, Lu J, Buchl SC, Sun L, Shah VH, Malhi H, Maiers JL. Coordinated signaling of activating transcription factor 6alpha and inositol-requiring enzyme 1alpha regulates hepatic stellate cell-mediated fibrogenesis in mice. Am J Physiol Gastrointest Liver Physiol. 2021 May 1; 320 (5):G864-G879 Epub 2021 Mar 17
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  31. Catala-Senent JF, Hidalgo MR, Berenguer M, Parthasarathy G, Malhi H, Malmierca-Merlo P, de la Iglesia-Vaya M, Garcia-Garcia F. Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies. Biol Sex Differ. 2021 Mar 25; 12 (1):29
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  32. Sehrawat TS, Arab JP, Liu M, Amrollahi P, Wan M, Fan J, Nakao Y, Pose E, Navarro-Corcuera A, Dasgupta D, Liao CY, He L, Mauer AS, Avitabile E, Ventura-Cots M, Bataller RA, Sanyal AJ, Chalasani NP, Heimbach JK, Watt KD, Gores GJ, Gines P, Kamath PS, Simonetto DA, Hu TY, Shah VH, Malhi H. Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis. Hepatology. 2021 Feb; 73 (2):571-585 Epub 2020 Oct 30
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  33. Nakao Y, Fukushima M, Mauer AS, Liao CY, Ferris A, Dasgupta D, Heppelmann CJ, Vanderboom PM, Saraswat M, Pandey A, Nair KS, Allen AM, Nakao K, Malhi H. A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity. Front Cell Dev Biol. 2021; 9:735001 Epub 2021 Nov 04
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  34. He L, Sehrawat TS, Verma VK, Navarro-Corcuera A, Sidhu G, Mauer A, Luo X, Katsumi T, Chen J, Shah S, Arab JP, Cao S, Kashkar H, Gores GJ, Malhi H, Shah VH. XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC. Front Physiol. 2021; 12:664222 Epub 2021 May 07
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  35. Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Nonalcoholic Steatohepatitis Promoting Kinases. Semin Liver Dis. 2020 Nov; 40 (4):346-357 Epub 2020 June 11
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  36. Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. 2020 Oct; 159(4):1487-1503.e17. Epub 2020 Jun 20.
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  37. Arab JP, Sehrawat TS, Simonetto DA, Verma VK, Feng D, Tang T, Dreyer K, Yan X, Daley WL, Sanyal A, Chalasani N, Radaeva S, Yang L, Vargas H, Ibacache M, Gao B, Gores GJ, Malhi H, Kamath PS, Shah VH. An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in Patients With Alcohol-associated Hepatitis. Hepatology. 2020 Aug; 72 (2):441-453 Epub 2020 Apr 27
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  38. Parthasarathy G, Revelo X, Malhi H. Pathogenesis of Nonalcoholic Steatohepatitis: An Overview. Hepatol Commun. 2020 Apr; 4 (4):478-492 Epub 2020 Jan 14
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  39. Yin Z, Murphy MC, Li J, Glaser KJ, Mauer AS, Mounajjed T, Therneau TM, Liu H, Malhi H, Manduca A, Ehman RL, Yin M. Prediction of nonalcoholic fatty liver disease (NAFLD) activity score (NAS) with multiparametric hepatic magnetic resonance imaging and elastography. Eur Radiol. 2019 Nov; 29 (11):5823-5831 Epub 2019 Mar 18
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  40. Song MJ, Malhi H. The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease. Pharmacol Ther. 2019 Nov; 203:107401 Epub 2019 Aug 13
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  41. Malhi H. Emerging role of extracellular vesicles in liver diseases. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1; 317 (5):G739-G749 Epub 2019 Sept 23
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  42. Li J, Liu H, Mauer AS, Lucien F, Raiter A, Bandla H, Mounajjed T, Yin Z, Glaser KJ, Yin M, Malhi H. Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis. Hepatol Commun. 2019 Sep; 3(9):1235-1249. Epub 2019 Jul 10.
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  43. Akazawa Y, Nakashima R, Matsuda K, Okamaoto K, Hirano R, Kawasaki H, Miuma S, Miyaaki H, Malhi H, Abiru S, Itoh M, Kondo H, Fukuoka J, Nakao K, Nakashima M. Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression. Mod Pathol. 2019 Jul; 32 (7):997-1007 Epub 2019 Feb 26
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  44. Maiers JL, Malhi H. Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis. Semin Liver Dis. 2019 May; 39 (2):235-248 Epub 2019 Mar 25
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  45. Liu Z, Li C, Kang N, Malhi H, Shah VH, Maiers JL. Transforming growth factor beta (TGFbeta) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation. J Biol Chem. 2019 Mar 1; 294 (9):3137-3151 Epub 2019 Jan 04
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  46. Russo N, Brown RS Jr, Shah SL, Krisko TI, Krumm CS, Nicholls HT, Mousa O, Malhi H, Schwartz RE, Lominadze Z, Rosenblatt R, Fortune BE, Pisa JF, Jesudian AB, Gupta V, Tafesh ZH. Hepatology Highlights. Hepatology. 2019 Feb; 69 (2):469-472
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  47. Russo N, Jesudian A, Shen NT, Brown RS Jr, Sugiyama A, Nicholls HT, Pisa JF, Krisko TI, Rosenblatt R, Tafesh ZH, Fortune BE, Mousa O, Schwartz RE, Gupta V, Kulai TB, Malhi H, Malhi H. Hepatology Highlights. Hepatology. 2019 Jan; 69 (1):1-4
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  48. Russo N, Jesudian A, Shen NT, Brown RS Jr, Sugiyama A, Nicholls HT, Pisa JF, Krisko TI, Rosenblatt R, Tafesh ZH, Fortune BE, Mousa O, Schwartz RE, Gupta V, Kulai TB, Malhi H, Malhi H. Hepatology Highlights. Hepatology. 2019 Jan; 69 (1):1-4
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  49. Shen NT, Brown RS Jr, Imai N, Krisko TI, Alves-Bezerra M, Nicholls HT, Kulai TB, Schwartz RE, Tafesh ZH, Jesudian A, Rosenblatt R, Fortune BE, Pisa JF, Mousa O, Malhi H, Gupta V. Hepatology Highlights. Hepatology. 2018 Dec; 68 (6):2049-2052
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  50. Zhang N, Jin W, Zhou S, Yang JD, Harmsen WS, Giama NH, Wongjarupong N, Heimbach JK, Watt KD, Malhi H, Therneau TM, Roberts LR. Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation. Cancer Med. 2018 Dec; 7 (12):5870-5878 Epub 2018 Nov 19
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  51. Wang XJ, Malhi H. Nonalcoholic Fatty Liver Disease. Ann Intern Med. 2018 Nov 6; 169 (9):ITC65-ITC80
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  52. Fukushima M, Dasgupta D, Mauer AS, Kakazu E, Nakao K, Malhi H. StAR-related lipid transfer domain 11 (STARD11)-mediated ceramide transport mediates extracellular vesicle biogenesis. J Biol Chem. 2018 Sep 28; 293 (39):15277-15289 Epub 2018 Aug 23
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  53. Shin J, Chen Y, Malhi H, Chen F, Yen J. Performance Evaluation of Adaptive Imaging Based on Multiphase Apodization with Cross-correlation: A Pilot Study in Abdominal Ultrasound. Ultrason Imaging. 2018 Jul; 40 (4):195-214 Epub 2018 May 08
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  54. Bandla H, Dasgupta D, Mauer AS, Nozickova B, Kumar S, Hirsova P, Graham RP, Malhi H. Deletion of endoplasmic reticulum stress-responsive co-chaperone p58(IPK) protects mice from diet-induced steatohepatitis. Hepatol Res. 2018 May; 48 (6):479-494 Epub 2018 Feb 09
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  55. Liao CY, Song MJ, Gao Y, Mauer AS, Revzin A, Malhi H. Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis. Front Immunol. 2018; 9:2980 Epub 2018 Dec 19
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  56. Mousa O, Malhi H, Schwartz RE. Zinc fingers for cold livers Hepatology. 2018; 68 (6):2051-2
  57. Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borras FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MA, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Gorecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzas EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekstrom K, El Andaloussi S, Elie-Caille C, Erdbrugger U, Falcon-Perez JM, Fatima F, Fish JE, Flores-Bellver M, Forsonits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gamez-Valero A, Gardiner C, Gartner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Gorgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ 2nd, Kornek M, Kosanovic MM, Kovacs AF, Kramer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lasser C, Laurent LC, Lavieu G, Lazaro-Ibanez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstons K, Llorente A, Lombard CA, Lorenowicz MJ, Lorincz AM, Lotvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG Jr, Meehan KL, Mertens I, Minciacchi VR, Moller A, Moller Jorgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, et al, Sharma S, van Wijnen AJ, Wolfram J. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018; 7 (1):1535750 Epub 2018 Nov 23
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  58. Malhi H, Camilleri M. Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases. Curr Opin Pharmacol. 2017 Dec; 37:80-86 Epub 2017 Nov 05
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  59. Bhanji RA, Narayanan P, Allen AM, Malhi H, Watt KD. Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis. Hepatology. 2017 Dec; 66 (6):2055-2065 Epub 2017 Oct 30
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  60. Greuter T, Malhi H, Gores GJ, Shah VH. Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis. JCI Insight. 2017 Sep 7; 2 (17) Epub 2017 Sept 07
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  61. Liu Y, Verma VK, Malhi H, Gores GJ, Kamath PS, Sanyal A, Chalasani N, Gao B, Shah VH. Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death. Am J Physiol Cell Physiol. 2017 Sep 1; 313 (3):C305-C313 Epub 2017 June 21
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  62. Yin M, Glaser KJ, Manduca A, Mounajjed T, Malhi H, Simonetto DA, Wang R, Yang L, Mao SA, Glorioso JM, Elgilani FM, Ward CJ, Harris PC, Nyberg SL, Shah VH, Ehman RL. Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography. Radiology. 2017 Sep; 284 (3):694-705 Epub 2017 Jan 27
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  63. Camilleri M, Malhi H, Acosta A. Gastrointestinal Complications of Obesity. Gastroenterology. 2017 May; 152 (7):1656-1670 Epub 2017 Feb 10
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  64. Mauer AS, Hirsova P, Maiers JL, Shah VH, Malhi H. Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1; 312 (3):G300-G313 Epub 2016 Dec 30
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  65. Maiers JL, Kostallari E, Mushref M, deAssuncao TM, Li H, Jalan-Sakrikar N, Huebert RC, Cao S, Malhi H, Shah VH. The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice. Hepatology. 2017 Mar; 65 (3):983-998 Epub 2016 Dec 31
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  66. Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, LaRusso NF, Gores GJ, Malhi H. Extracellular vesicles in liver pathobiology: Small particles with big impact. Hepatology. 2016 Dec; 64 (6):2219-2233 Epub 2016 Oct 20
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  67. Hirsova P, Ibrahim SH, Ibrabim SH, Gores GJ, Malhi H. Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. J Lipid Res. 2016 Oct; 57 (10):1758-1770 Epub 2016 Apr 05
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  68. Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame. Dig Dis Sci. 2016 May; 61 (5):1325-36 Epub 2015 Dec 01
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  69. Malhi H, Allen AM, Watt KD. Nonalcoholic fatty liver: optimizing pretransplant selection and posttransplant care to maximize survival. Curr Opin Organ Transplant. 2016 Apr; 21 (2):99-106
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  70. Hirsova P, Ibrahim SH, Krishnan A, Verma VK, Bronk SF, Werneburg NW, Charlton MR, Shah VH, Malhi H, Gores GJ. Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. Gastroenterology. 2016 Apr; 150 (4):956-67 Epub 2016 Jan 05
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  71. Verma VK, Li H, Wang R, Hirsova P, Mushref M, Liu Y, Cao S, Contreras PC, Malhi H, Kamath PS, Gores GJ, Shah VH. Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. J Hepatol. 2016 Mar; 64 (3):651-60 Epub 2015 Nov 26
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  72. Ibrahim SH, Hirsova P, Tomita K, Bronk SF, Werneburg NW, Harrison SA, Goodfellow VS, Malhi H, Gores GJ. Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology. 2016 Mar; 63 (3):731-44 Epub 2015 Dec 11
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  73. Kakazu E, Mauer AS, Yin M, Malhi H. Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner. J Lipid Res. 2016 Feb; 57 (2):233-45 Epub 2015 Nov 30
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  74. Hirsova P, Ibrabim SH, Gores GJ, Malhi H. Thematic review series: Lipotoxicity: many roads to cell dysfunction and cell death lipotoxic lethal and sublethal stress signaling in hepatocytes: Relevance to NASH pathogenesis Journal of Lipid Research. 2016; 57: (10)1758-70.
  75. Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol. 2015 May; 62 (5):1156-63 Epub 2014 Nov 28
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  76. Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ. The IRE1 alpha/XBP1s pathway is essential for the glucose response and protection of beta cells. PLoS Biol. 2015; 13(10):e1002277.
    View PubMed
  77. Hirsova P, Ibrahim SH, Bronk SF, Krishnan A, Werneburg NW, Verma VK, Shah VH, Malhi H, Gores GJ. Lipotoxicity Induces Release of Proinflammatory Extracellular Vesicles from Hepatocytes. Gastroenterology. 2015.
  78. Hassler JR, Scheuner DL, Bai Y, Sartor M, Cavacoli J, Malhi H, Song B, Back SH, George JS, Davis C, Wu P, Ferris SP, Wang S, Han J, Liu M, Arvan P, Kaufman RJ. ß-Cell Specific Deletion of IRE1α Causes a Diabetic Phenotype Due to Faulty Insulin Synthesis and Maturation. PLoS Genetics under review. 2015.
  79. Malhi H. MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS. Curr Pathobiol Rep. 2014 Sep; 2 (3):117-122
    View PubMed
  80. Miyamoto Y, Mauer AS, Kumar S, Mott JL, Malhi H. Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein. PLoS One. 2014; 9 (10):e109637 Epub 2014 Oct 14
    View PubMed
  81. Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. CEBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. J Biol Chem. 2013 Jun 28; 288: (26)18624-42.
    View PubMed
  82. Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ. ER stress signalling through eIF2alpha and CHOP, but not IRE1alpha, attenuates adipogenesis in mice. Diabetologia. 2013 Apr; 56: (4)911-24.
    View PubMed
  83. Guicciardi ME, Malhi H, Mott JL, Gores GJ. Apoptosis and necrosis in the liver. Compr Physiol. 2013 Apr; 3 (2):977-1010
    View PubMed
  84. Fisher JE, McKenzie TJ, Lillegard JB, Yu Y, Juskewitch JE, Nedredal GI, Brunn GJ, Yi ES, Malhi H, Smyrk TC, Nyberg SL. Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure. J Surg Res. 2013 Mar; 180 (1):147-55 Epub 2012 Dec 20
    View PubMed
  85. Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011 Apr; 54 (4):795-809 Epub 2010 Nov 13
    View PubMed
  86. Malhi H, Guicciardi ME, Gores GJ. Hepatocyte death: a clear and present danger. Physiol Rev. 2010 Jul; 90 (3):1165-94
    View PubMed
  87. Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008 Nov; 28 (4):360-9 Epub 2008 Oct 27
    View PubMed
  88. Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology. 2008 May; 134 (6):1641-54
    View PubMed
  89. Malhi H, Joseph B, Schilsky ML, Gupta S. Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease. Regen Med. 2008 Mar; 3: (2)165-73.
    View PubMed
  90. Malhi H, Gores GJ. Molelcular Mechanisms of Lipotoxicity in Non Alcoholic Fatty Liver Disease. Seminars in Liver disease. 2008; 28(4):360-9.
  91. Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ. Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem. 2007 Sep 14; 282 (37):27141-27154 Epub 2007 July 11
    View PubMed
  92. Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut. 2007 Aug; 56 (8):1124-31 Epub 2007 Apr 30
    View PubMed
  93. Malhi H, Gores GJ. Cholangiocarcinoma: modern advances in understanding a deadly old disease. J Hepatol. 2006 Dec; 45 (6):856-67 Epub 2006 Sept 25
    View PubMed
  94. Malhi H, Gores GJ. TRAIL resistance results in cancer progression: a TRAIL to perdition? Oncogene. 2006 Nov 30; 25: (56)7333-5.
    View PubMed
  95. Malhi H, Gores GJ. Review article: the modern diagnosis and therapy of cholangiocarcinoma. Aliment Pharmacol Ther. 2006 May 01; 23: (9)1287-96.
    View PubMed
  96. Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem. 2006 Apr 28; 281 (17):12093-101 Epub 2006 Feb 27
    View PubMed
  97. Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology. 2006 Feb; 43 (2 Suppl 1):S31-44
    View PubMed
  98. Malhi H, Atac B, Daly AK, Gupta S. Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication. Postgrad Med J. 2004 Feb; 80: (940)107-9.
    View PubMed
  99. Giri RK, Malhi H, Joseph B, Kandimalla J, Gupta S. Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathways. Exp Cell Res. 2003 Dec 10; 291: (2)451-62.
    View PubMed
  100. Joseph B, Bhargava KK, Malhi H, Schilsky ML, Jain D, Palestro CJ, Gupta S. Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes. Eur J Nucl Med Mol Imaging. 2003 Jul; 30: (7)1024-31.
    View PubMed
  101. Wege H, Le HT, Chui MS, Liu L, Wu J, Giri R, Malhi H, Sappal BS, Kumaran V, Gupta S, Zern MA. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology. 2003 Feb; 124: (2)432-44.
    View PubMed
  102. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology. 2002 Nov; 123: (5)1677-85.
    View PubMed
  103. Malhi H, Gorla GR, Irani AN, Annamaneni P, Gupta S. Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation. Proc Natl Acad Sci U S A. 2002 Oct 01; 99: (20)13114-9.
    View PubMed
  104. Cho JJ, Malhi H, Wang R, Joseph B, Ludlow JW, Susick R, Gupta S. Enzymatically labeled chromosomal probes for in situ identification of human cells in xenogeneic transplant models. Nat Med. 2002 Sep; 8: (9)1033-6.
    View PubMed
  105. Malhi H, Annamaneni P, Slehria S, Joseph B, Bhargava KK, Palestro CJ, Novikoff PM, Gupta S. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. Hepatology. 2002 Jul; 36: (1)112-21.
    View PubMed
  106. Malhi H, Irani AN, Gagandeep S, Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. J Cell Sci. 2002 Jul 01; 115: (Pt 13)2679-88.
    View PubMed
  107. Malhi H, Irani AN, Volenberg I, Schilsky ML, Gupta S. Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver disease. Gastroenterology. 2002 Feb; 122: (2)438-47.
    View PubMed
  108. Malhi H, Bhargava KK, Afriyie MO, Volenberg I, Schilsky ML, Palestro CJ, Gupta S. 99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease. J Nucl Med. 2002 Feb; 43: (2)246-52.
    View PubMed
  109. Gorla GR, Malhi H, Gupta S. Polyploidy associated with oxidative injury attenuates proliferative potential of cells. J Cell Sci. 2001 Aug; 114: (Pt 16)2943-51.
    View PubMed
  110. Irani AN, Malhi H, Slehria S, Gorla GR, Volenberg I, Schilsky ML, Gupta S. Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease. Mol Ther. 2001 Mar; 3: (3)302-9.
    View PubMed
  111. Malhi H, Gupta S. Hepatocyte transplantation: new horizons and challenges. J Hepatobiliary Pancreat Surg. 2001; 8: (1)40-50.
    View PubMed
  112. Gupta S, Malhi H, Gorla GR. Re-Engineering the liver with natural biomaterials. Yonsei Med J. 2000 Dec; 41: (6)814-24.
    View PubMed
  113. Gupta S, Rajvanshi P, Malhi H, Slehria S, Sokhi RP, Vasa SR, Dabeva M, Shafritz DA, Kerr. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am J Physiol Gastrointest Liver Physiol. 2000 Oct; 279: (4)G815-26.
    View PubMed
  114. Malhi H, Irani AN, Rajvanshi P, Suadicani SO, Spray DC, McDonald TV, Gupta S. KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting. J Biol Chem. 2000 Aug 25; 275: (34)26050-7.
    View PubMed
  115. Zahler MH, Irani A, Malhi H, Reutens AT, Albanese C, Bouzahzah B, Joyce D, Gupta S, Pestell RG. The application of a lentiviral vector for gene transfer in fetal human hepatocytes. J Gene Med. 2000 May-Jun; 2: (3)186-93.
    View PubMed
  116. Gupta S, Malhi H, Gagandeep S, Novikoff P. Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapy. J Gene Med. 1999 Nov-Dec; 1: (6)386-92.
    View PubMed
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