Holmium laser prostate surgery is a minimally invasive treatment for an enlarged prostate. Also known as holmium laser enucleation of the prostate (HoLEP), the procedure uses a laser to remove tissue that is blocking urine flow through the prostate. A separate instrument is then used to cut the prostate tissue into easily removable fragments.

HoLEP is similar to open prostate surgery but requires no incisions. It can be an option for men with a severely enlarged prostate.

HoLEP removes the entire portion of the prostate that can block urine flow. The treatment provides a lasting solution for men with an enlarged prostate — a condition known as benign prostatic hyperplasia (BPH). HoLEP also preserves removed tissue so that it can be examined in the laboratory for other conditions, including prostate cancer.

As with other types of prostate laser surgery, HoLEP can offer faster recovery and symptom relief compared with traditional prostate surgery. Less than 2 percent of men who have HoLEP need subsequent re-treatment for urinary symptoms.

Read more about benign prostatic hyperplasia (BPH) and prostate laser surgery.

Mayo Clinic's approach

June 28, 2016
  1. AskMayoExpert. Holmium laser enucleation of the prostate. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016.
  2. Wein AJ, et al., eds. Minimally invasive and endoscopic management of benign prostatic hyperplasia. In: Campbell-Walsh Urology. 11th ed. Philadelphia, Pa.: Elsevier; 2016. http://www.clinicalkey.com. Accessed May 11, 2016.
  3. Cunningham GR, et al. Transurethral procedures for treating benign prostatic hyperplasia. http://www.uptodate.com/home. Accessed May 11, 2016.
  4. Brunkhorst O, et al. Evaluation of the learning curve for holmium laser enucleation of the prostate using multiple outcome measures. Urology. 2015;86:824.
  5. Abdul-Muhsin H, et al. Analysis of benign prostatic hyperplasia patients' perspective through a third-party administered survey. Urology. 2016;88:155.
  6. Jaeger CD, et al. Holmium laser enucleation (HoLEP) and photoselective vaporization of the prostate (PVP) for patients with benign prostatic hyperplasia (BPH) and chronic urinary retention. BJU International. 2015;115:295.
  7. Cook AJ. Allscripts EPSi. Mayo Clinic, Rochester, Minn. May 12, 2016.