Intrauterine insemination is a relatively simple and safe procedure, and the risk of serious complications is low. Risks include:

  • Infection. There's a slight risk of developing an infection as a result of the procedure.
  • Spotting. Sometimes the process of placing the catheter in the uterus causes a small amount of vaginal bleeding. This doesn't usually have an effect on the chance of pregnancy.
  • Multiple pregnancy. IUI itself isn't associated with an increased risk of a multiple pregnancy — twins, triplets or more. But, when coordinated with ovulation-inducing medications, the risk of a multiple pregnancy increases significantly. A multiple pregnancy has higher risks than a single pregnancy does, including early labor and low birth weight.
June 21, 2016
  1. Treating infertility. American College of Obstetricians and Gynecologists. http://www.acog.org/Patients/FAQs/Treating-Infertility. Accessed April 7, 2016.
  2. Infertility FAQs. Centers for Disease Control and Prevention. http://www.cdc.gov/reproductivehealth/Infertility/. Accessed April 7, 2016.
  3. Infertility fact sheet. Womenshealth.gov. http://www.womenshealth.gov/publications/our-publications/fact-sheet/infertility.html. Accessed April 8, 2016.
  4. Ginsburg ES. Procedure for intrauterine insemination (IUI) using processed sperm. http://www.uptodate.com/home. Accessed April 8, 2016.
  5. Intrauterine insemination (IUI). ReproductiveFacts.org. http://www.reproductivefacts.org/awards/detail.aspx?id=8576 Accessed April 18, 2016.
  6. Luco SM, et al. The evaluation of pre and post processing semen analysis parameters at the time of intrauterine insemination in couples diagnosed with male factor infertility and pregnancy rates based on stimulation agent. A retrospective cohort study. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2014;179:159.
  7. Hornstein MD, et al. Unexplained infertility. http://www.uptodate.com/home. Accessed April 18, 2016.
  8. Coddington III CC (expert opinion). Mayo Clinic, Rochester, Minn. April 18, 2016.