Proper Use

Drug information provided by: Merative, Micromedex®

A nurse or other trained health professional will give you or your child this medicine. It is given as a shot under your skin, usually on the upper arms, stomach, or thigh once every 4 weeks.

Mepolizumab injection may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to inject the medicine. Be sure that you understand exactly how to use this.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully . Ask your doctor if you have questions.

If you use this medicine at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems. Do not inject into scars, moles, or skin areas that are red, bruised, tender, hard, or not intact.

This medicine is available in 2 forms. You may use a prefilled syringe or a prefilled autoinjector.

Allow the prefilled syringe or prefilled autoinjector to warm to room temperature 30 minutes before using it. Do not warm it in any other way.

Check the liquid in the prefilled syringe or prefilled autoinjector. It should be clear and colorless or slightly yellow to slightly brown. Do not use this medicine if it is cloudy or if there are particles in it. Do not use the prefilled syringe or autoinjector if it looks damaged or broken.

Use all of the medicine in each prefilled syringe or autoinjector. Use each prefilled syringe and autoinjector only one time. Do not save an open syringe or autoinjector.

This medicine must be injected within 8 hours after removal from the carton. Throw away if not used within 8 hours.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage forms (prefilled syringe or prefilled autoinjector):
    • For severe asthma:
      • Adults and children 12 years of age and older—100 milligrams (mg) injected under your skin once every 4 weeks.
      • Children 6 to 11 years of age—40 mg injected under your skin once every 4 weeks.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.
    • For CRSwNP:
      • Adults—100 milligrams (mg) injected under your skin once every 4 weeks.
      • Children—Use and dose must be determined by your doctor.
    • For EGPA:
      • Adults—300 milligrams (mg) injected under your skin once every 4 weeks (given as 3 separate 100 mg injections injected 5 cm apart if given at the same injection site).
      • Children—Use and dose must be determined by your doctor.
    • For HES:
      • Adults and children 12 years of age and older—300 milligrams (mg) injected under your skin once every 4 weeks (given as 3 separate 100 mg injections injected 5 cm apart if given at the same injection site).
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Protect this medicine from direct light. Keep it in its original package until you are ready to use it. Do not shake. You may also keep an unopened carton at room temperature for up to 7 days. Throw away any medicine left out of the refrigerator for more than 7 days.

Throw away used syringes in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.

Portions of this document last updated: March 01, 2024

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