Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen and oxycodone combination in children younger than 14 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxycodone and ibuprofen combination in the elderly. However, elderly patients who may be more sensitive than younger adults to the effects of ibuprofen and oxycodone combination, are more likely to have kidney, lung, or stomach problems, which may require caution in patients receiving oxycodone and ibuprofen combination.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Ketorolac
  • Levoketoconazole
  • Nalmefene
  • Naltrexone
  • Safinamide
  • Samidorphan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Abiraterone Acetate
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Acepromazine
  • Aclidinium
  • Adagrasib
  • Alfentanil
  • Almotriptan
  • Alosetron
  • Alprazolam
  • Alvimopan
  • Amantadine
  • Amifampridine
  • Amiloride
  • Amineptine
  • Amiodarone
  • Amitriptyline
  • Amitriptylinoxide
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amprenavir
  • Amtolmetin Guacil
  • Anagrelide
  • Anileridine
  • Apalutamide
  • Apixaban
  • Aprepitant
  • Ardeparin
  • Argatroban
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Armodafinil
  • Asciminib
  • Asenapine
  • Aspirin
  • Atazanavir
  • Atropine
  • Avacopan
  • Baclofen
  • Balsalazide
  • Belladonna
  • Bemetizide
  • Bemiparin
  • Bendroflumethiazide
  • Benperidol
  • Bentazepam
  • Benzhydrocodone
  • Benzphetamine
  • Benzthiazide
  • Benztropine
  • Berotralstat
  • Betrixaban
  • Biperiden
  • Bismuth Subsalicylate
  • Bivalirudin
  • Boceprevir
  • Bosentan
  • Bromazepam
  • Bromfenac
  • Bromopride
  • Brompheniramine
  • Budesonide
  • Bufexamac
  • Bumetanide
  • Buprenorphine
  • Bupropion
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Calcium Oxybate
  • Cangrelor
  • Cannabidiol
  • Cannabis
  • Carbamazepine
  • Carbinoxamine
  • Carisoprodol
  • Carphenazine
  • Celecoxib
  • Cenobamate
  • Ceritinib
  • Certoparin
  • Cetirizine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorzoxazone
  • Choline Magnesium Trisalicylate
  • Choline Salicylate
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clidinium
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Clorazepate
  • Cloxazolam
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Cyclopenthiazide
  • Cyclopentolate
  • Cyclosporine
  • Cyclothiazide
  • Cyproheptadine
  • Dabigatran Etexilate
  • Dabrafenib
  • Dalteparin
  • Danaparoid
  • Dantrolene
  • Daridorexant
  • Darifenacin
  • Darunavir
  • Deflazacort
  • Delavirdine
  • Delorazepam
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan
  • Dezocine
  • Diacetylmorphine
  • Diazepam
  • Diazoxide
  • Dibenzepin
  • Dichloralphenazone
  • Diclofenac
  • Dicyclomine
  • Difenoxin
  • Diflunisal
  • Digoxin
  • Dihydrocodeine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenoxylate
  • Dipyridamole
  • Dipyrone
  • Dolasetron
  • Donepezil
  • Dothiepin
  • Doxepin
  • Doxylamine
  • Dronedarone
  • Droperidol
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Efavirenz
  • Elagolix
  • Eletriptan
  • Emtricitabine
  • Enasidenib
  • Enflurane
  • Enoxaparin
  • Enzalutamide
  • Eplerenone
  • Epoprostenol
  • Eptifibatide
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Eslicarbazepine Acetate
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethchlorvynol
  • Ethopropazine
  • Ethylmorphine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etozolin
  • Etravirine
  • Fedratinib
  • Felbinac
  • Fenfluramine
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fesoterodine
  • Feverfew
  • Fexinidazole
  • Flavoxate
  • Flibanserin
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Flunitrazepam
  • Fluoxetine
  • Fluphenazine
  • Flurazepam
  • Flurbiprofen
  • Fluspirilene
  • Fluvoxamine
  • Fondaparinux
  • Fosamprenavir
  • Fosaprepitant
  • Fosnetupitant
  • Fosphenytoin
  • Fospropofol
  • Frovatriptan
  • Furazolidone
  • Furosemide
  • Gabapentin
  • Gabapentin Enacarbil
  • Gepirone
  • Ginkgo
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Gossypol
  • Granisetron
  • Halazepam
  • Haloperidol
  • Halothane
  • Heparin
  • Hexobarbital
  • Homatropine
  • Hydrochlorothiazide
  • Hydrocodone
  • Hydrocortisone
  • Hydroflumethiazide
  • Hydromorphone
  • Hydroxyamphetamine
  • Hydroxytryptophan
  • Hydroxyzine
  • Hyoscyamine
  • Idelalisib
  • Iloprost
  • Imatinib
  • Imipramine
  • Indapamide
  • Indinavir
  • Indomethacin
  • Inotersen
  • Ipratropium
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Itraconazole
  • Ivacaftor
  • Ketamine
  • Ketazolam
  • Ketobemidone
  • Ketoconazole
  • Ketoprofen
  • Lacosamide
  • Lanreotide
  • Larotrectinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenacapavir
  • Lepirudin
  • Letermovir
  • Levocetirizine
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lofexidine
  • Lomitapide
  • Lopinavir
  • Loprazolam
  • Lorazepam
  • Lorcaserin
  • Lorlatinib
  • Lormetazepam
  • Lornoxicam
  • Loxapine
  • Loxoprofen
  • Lumacaftor
  • Lumiracoxib
  • Magnesium Oxybate
  • Mavacamten
  • Meadowsweet
  • Meclizine
  • Meclofenamate
  • Medazepam
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Melperone
  • Melphalan
  • Mepenzolate
  • Meperidine
  • Mephobarbital
  • Meprobamate
  • Meptazinol
  • Mesalamine
  • Mesoridazine
  • Metaclazepam
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methdilazine
  • Methocarbamol
  • Methohexital
  • Methotrexate
  • Methotrimeprazine
  • Methyclothiazide
  • Methylene Blue
  • Methylnaltrexone
  • Methylprednisolone
  • Metoclopramide
  • Metolazone
  • Mibefradil
  • Midazolam
  • Mifepristone
  • Milnacipran
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Mobocertinib
  • Moclobemide
  • Modafinil
  • Molindone
  • Moricizine
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Nadroparin
  • Nafcillin
  • Nalbuphine
  • Nalorphine
  • Naloxone
  • Naproxen
  • Naratriptan
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Netupitant
  • Nevirapine
  • Nialamide
  • Nicomorphine
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nirogacestat
  • Nitrazepam
  • Nitrous Oxide
  • Nordazepam
  • Nortriptyline
  • Octreotide
  • Olanzapine
  • Oliceridine
  • Olsalazine Sodium
  • Omaveloxolone
  • Ondansetron
  • Opipramol
  • Opium
  • Opium Alkaloids
  • Orphenadrine
  • Oxaprozin
  • Oxazepam
  • Oxcarbazepine
  • Oxitropium Bromide
  • Oxybutynin
  • Oxymorphone
  • Oxyphenbutazone
  • Ozanimod
  • Palbociclib
  • Palonosetron
  • Papaveretum
  • Parecoxib
  • Paregoric
  • Parnaparin
  • Paroxetine
  • Pemetrexed
  • Pentazocine
  • Pentobarbital
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Perampanel
  • Perazine
  • Periciazine
  • Perphenazine
  • Phenelzine
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Pimozide
  • Pinazepam
  • Pipenzolate Bromide
  • Piperacetazine
  • Pipotiazine
  • Pirenzepine
  • Piretanide
  • Piritramide
  • Piroxicam
  • Pirtobrutinib
  • Polythiazide
  • Posaconazole
  • Potassium Citrate
  • Potassium Oxybate
  • Pranoprofen
  • Prasugrel
  • Prazepam
  • Prednisolone
  • Prednisone
  • Pregabalin
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Procyclidine
  • Proglumetacin
  • Promazine
  • Promethazine
  • Propantheline
  • Propiverine
  • Propofol
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinethazone
  • Quinidine
  • Quinine
  • Ramelteon
  • Ranitidine
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Remimazolam
  • Remoxipride
  • Repotrectinib
  • Reviparin
  • Ribociclib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritlecitinib
  • Ritonavir
  • Rivaroxaban
  • Rizatriptan
  • Rofecoxib
  • Rolapitant
  • Ropeginterferon Alfa-2b-njft
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Selexipag
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sibutramine
  • Sodium Oxybate
  • Sodium Salicylate
  • Solifenacin
  • Sotorasib
  • Spironolactone
  • Stramonium
  • Sufentanil
  • Sulfasalazine
  • Sulfinpyrazone
  • Sulindac
  • Sulodexide
  • Sulpiride
  • Sumatriptan
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Taurursodiol
  • Telaprevir
  • Telithromycin
  • Temazepam
  • Tenofovir Alafenamide
  • Tenofovir Disoproxil Fumarate
  • Tenoxicam
  • Terbinafine
  • Terodiline
  • Tetrazepam
  • Thiethylperazine
  • Thiopental
  • Thiopropazate
  • Thioridazine
  • Thiothixene
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tilidine
  • Tinzaparin
  • Tiotropium
  • Tirofiban
  • Tizanidine
  • Tocilizumab
  • Tolfenamic Acid
  • Tolmetin
  • Tolonium Chloride
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Trichlormethiazide
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trihexyphenidyl
  • Trimeprazine
  • Trimipramine
  • Trofinetide
  • Tropicamide
  • Trospium
  • Tryptophan
  • Tucatinib
  • Umeclidinium
  • Valdecoxib
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vonoprazan
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Warfarin
  • Xipamide
  • Zaleplon
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zopiclone
  • Zotepine
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Amikacin
  • Atenolol
  • Azilsartan
  • Azilsartan Medoxomil
  • Benazepril
  • Betaxolol
  • Bisoprolol
  • Candesartan
  • Captopril
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Enalapril
  • Enalaprilat
  • Eprosartan
  • Esmolol
  • Fosinopril
  • Irbesartan
  • Labetalol
  • Levobunolol
  • Lisinopril
  • Losartan
  • Metipranolol
  • Metoprolol
  • Moexipril
  • Nadolol
  • Nebivolol
  • Olmesartan
  • Oxprenolol
  • Penbutolol
  • Perindopril
  • Pindolol
  • Propranolol
  • Quinapril
  • Ramipril
  • Sotalol
  • Spirapril
  • St John's Wort
  • Telmisartan
  • Timolol
  • Trandolapril
  • Valsartan

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol
  • Grapefruit Juice
  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Addison's disease (adrenal gland problem) or
  • Alcohol abuse, history of or
  • Brain tumor or
  • Breathing or lung problems (eg, asthma, COPD, cor pulmonale, hypercapnia, hypoxia) or
  • Depression, history of or
  • Drug abuse or dependence, especially narcotic abuse or dependence, or history of or
  • Enlarged prostate (BPH, prostatic hypertrophy) or
  • Head injury or
  • Hypothyroidism (underactive thyroid) or
  • Kidney disease, severe or
  • Kyphoscoliosis (curvature of spine that can cause breathing problems) or
  • Liver disease, severe or
  • Problems with urination or
  • Psychosis (mental illness) or
  • Systemic lupus erythematosus (SLE) or
  • Weakened physical condition—Use with caution. May increase risk for more serious side effects.
  • Anemia or
  • Bleeding problems or
  • Dehydration or
  • Edema (fluid retention) or
  • Heart attack, recent or
  • Heart disease (eg, congestive heart failure) or
  • Hypertension (high blood pressure) or
  • Hypotension (low blood pressure) or
  • Kidney disease or
  • Liver disease or
  • Pancreatitis (inflammation of the pancreas) or
  • Seizures, history of or
  • Stomach ulcers or bleeding, history of or
  • Stroke, history of—Use with caution. May make these conditions worse.
  • Aspirin-sensitive asthma or
  • Aspirin sensitivity, history of or
  • Heart surgery (eg, coronary artery bypass graft [CABG]) or
  • Lung or breathing problems (eg, asthma, respiratory depression), severe or
  • Stomach or bowel blockage (eg, paralytic ileus)—Should not be used in patients with these conditions.

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Portions of this document last updated: April 01, 2024

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