Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of warfarin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of warfarin in the elderly. However, elderly patients may require caution and an adjustment in the dose, especially those who are at risk of bleeding.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Defibrotide
  • Tamoxifen
  • Viloxazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Abciximab
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Adagrasib
  • Adalimumab
  • Alefacept
  • Alipogene Tiparvovec
  • Allopurinol
  • Alteplase, Recombinant
  • Amiodarone
  • Amoxicillin
  • Ampicillin
  • Amtolmetin Guacil
  • Anagrelide
  • Anistreplase
  • Apalutamide
  • Apixaban
  • Asciminib
  • Aspirin
  • Atazanavir
  • Azithromycin
  • Bemiparin
  • Betrixaban
  • Bicalutamide
  • Bimekizumab-bkzx
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Cabozantinib
  • Cangrelor
  • Cannabidiol
  • Cannabis
  • Capecitabine
  • Caplacizumab-yhdp
  • Capmatinib
  • Carbenicillin
  • Carboplatin
  • Cefadroxil
  • Cefdinir
  • Cefepime
  • Cefixime
  • Cefotaxime
  • Cefpodoxime
  • Ceftaroline Fosamil
  • Ceftazidime
  • Ceftibuten
  • Ceftizoxime
  • Celecoxib
  • Cephalexin
  • Cephalothin
  • Cephapirin
  • Cephradine
  • Ceritinib
  • Chamomile
  • Choline Salicylate
  • Cilostazol
  • Ciprofibrate
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clonixin
  • Clopidogrel
  • Cloxacillin
  • Cobicistat
  • Collagenase, Clostridium histolyticum
  • Curcumin
  • Cyclophosphamide
  • Dabigatran Etexilate
  • Dabrafenib
  • Daclatasvir
  • Dalteparin
  • Danaparoid
  • Dapsone
  • Darunavir
  • Dasabuvir
  • Deferasirox
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Dicloxacillin
  • Diflunisal
  • Dihydroartemisinin
  • Dipyridamole
  • Dipyrone
  • Doxifluridine
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Drotrecogin Alfa
  • Droxicam
  • Duloxetine
  • Econazole
  • Edoxaban
  • Efavirenz
  • Elbasvir
  • Elvitegravir
  • Enasidenib
  • Enoxacin
  • Enoxaparin
  • Entacapone
  • Enzalutamide
  • Epoprostenol
  • Eptifibatide
  • Erlotinib
  • Erythromycin
  • Escitalopram
  • Etodolac
  • Etofenamate
  • Etoposide
  • Etoricoxib
  • Etravirine
  • Felbinac
  • Fenofibrate
  • Fenofibric Acid
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fish Oil
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluorouracil
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosnetupitant
  • Garlic
  • Gatifloxacin
  • Gemcitabine
  • Gemfibrozil
  • Gemifloxacin
  • Ginkgo
  • Glucagon
  • Grazoprevir
  • Ibrutinib
  • Ibuprofen
  • Iloprost
  • Imatinib
  • Indomethacin
  • Infliximab
  • Influenza Virus Vaccine
  • Inotersen
  • Itraconazole
  • Ivacaftor
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Ledipasvir
  • Leflunomide
  • Leniolisib
  • Lepirudin
  • Letermovir
  • Levocarnitine
  • Levofloxacin
  • Levomilnacipran
  • Levothyroxine
  • Linezolid
  • Lomitapide
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Lycium
  • Mavacamten
  • Mechlorethamine
  • Meclofenamate
  • Mefenamic Acid
  • Megestrol
  • Meloxicam
  • Melphalan
  • Mercaptopurine
  • Methicillin
  • Methotrexate
  • Methylphenidate
  • Methyl Salicylate
  • Metronidazole
  • Miconazole
  • Milk Thistle
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Morniflumate
  • Moxalactam
  • Moxifloxacin
  • Nabumetone
  • Nadroparin
  • Nafcillin
  • Nalidixic Acid
  • Nandrolone
  • Naproxen
  • Nepafenac
  • Netupitant
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nintedanib
  • Nitisinone
  • Norfloxacin
  • Noscapine
  • Obeticholic Acid
  • Ofloxacin
  • Omadacycline
  • Ombitasvir
  • Omeprazole
  • Oritavancin
  • Orlistat
  • Oseltamivir
  • Oxacillin
  • Oxaliplatin
  • Oxandrolone
  • Oxaprozin
  • Oxyphenbutazone
  • Oxypurinol
  • Papaya
  • Parecoxib
  • Paritaprevir
  • Paroxetine
  • Peginterferon Alfa-2b
  • Penicillin G
  • Penicillin V
  • Pentosan Polysulfate Sodium
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piperacillin
  • Piracetam
  • Piroxicam
  • Pixantrone
  • Posaconazole
  • Pranoprofen
  • Prasugrel
  • Primidone
  • Procarbazine
  • Proglumetacin
  • Proguanil
  • Propyphenazone
  • Proquazone
  • Regorafenib
  • Remdesivir
  • Reteplase, Recombinant
  • Ribavirin
  • Rivaroxaban
  • Rofecoxib
  • Ropinirole
  • Rosuvastatin
  • Roxithromycin
  • Rucaparib
  • Sarecycline
  • Secnidazole
  • Selexipag
  • Selumetinib
  • Sertraline
  • Simeprevir
  • Simvastatin
  • Sitaxsentan
  • Sofosbuvir
  • Sparsentan
  • St John's Wort
  • Streptokinase
  • Sulfamethoxazole
  • Sulfisoxazole
  • Sulindac
  • Sultamicillin
  • Tan-Shen
  • Taurursodiol
  • Tegafur
  • Telithromycin
  • Tenecteplase
  • Tenoxicam
  • Teriflunomide
  • Testosterone
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticarcillin
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tirzepatide
  • Tocilizumab
  • Tocophersolan
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Tramadol
  • Trazodone
  • Treprostinil
  • Turmeric
  • Urokinase
  • Ustekinumab
  • Valdecoxib
  • Valproic Acid
  • Velpatasvir
  • Venlafaxine
  • Vilazodone
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vindesine
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Voxilaprevir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acetaminophen
  • Aminoglutethimide
  • Amitriptyline
  • Amprenavir
  • Apazone
  • Aprepitant
  • Argatroban
  • Atovaquone
  • Azathioprine
  • Balsalazide
  • Bee Pollen
  • Benorilate
  • Benzbromarone
  • Bosentan
  • Butabarbital
  • Butalbital
  • Carbamazepine
  • Carbimazole
  • Cefamandole
  • Cefazolin
  • Ceftriaxone
  • Chitosan
  • Chloral Hydrate
  • Chlorthalidone
  • Cholestyramine
  • Choline Magnesium Trisalicylate
  • Chondroitin
  • Cimetidine
  • Cisapride
  • Cisplatin
  • Coenzyme Q10
  • Colesevelam
  • Cyclosporine
  • Danazol
  • Desogestrel
  • Dexamethasone
  • Dexlansoprazole
  • Dienogest
  • Disopyramide
  • Disulfiram
  • Dong Quai
  • Doxepin
  • Drospirenone
  • Eslicarbazepine Acetate
  • Esomeprazole
  • Estradiol
  • Eterobarb
  • Ethinyl Estradiol
  • Ethynodiol
  • Exenatide
  • Felbamate
  • Fluoxymesterone
  • Fluvastatin
  • Fosaprepitant
  • Gefitinib
  • Gestodene
  • Ginger
  • Ginseng
  • Glucosamine
  • Glyburide
  • Griseofulvin
  • Heparin
  • Ifosfamide
  • Indoprofen
  • Isoniazid
  • Isoxicam
  • Ivermectin
  • Lactulose
  • Lansoprazole
  • Levamisole
  • Levonorgestrel
  • Lopinavir
  • Melatonin
  • Menatetrenone
  • Menthol
  • Mephobarbital
  • Mesalamine
  • Mesna
  • Mestranol
  • Methimazole
  • Methylprednisolone
  • Methyltestosterone
  • Methylthiouracil
  • Moricizine
  • Nelfinavir
  • Nevirapine
  • Niacin
  • Nilutamide
  • Nirmatrelvir
  • Nomegestrol
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Pantoprazole
  • Pentoxifylline
  • Phytonadione
  • Polyacrylamide
  • Potassium Iodide
  • Prednisone
  • Propafenone
  • Propoxyphene
  • Propylthiouracil
  • Quetiapine
  • Ranitidine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Secobarbital
  • Semaglutide
  • Sodium Salicylate
  • Sodium Thiosalicylate
  • Sorafenib
  • Stanozolol
  • Sucralfate
  • Sulfasalazine
  • Sulfinpyrazone
  • Tenidap
  • Terbinafine
  • Tigecycline
  • Tolterodine
  • Trastuzumab
  • Trolamine Salicylate
  • Vancomycin
  • Venetoclax
  • Vitamin A
  • Vitamin E
  • Vorinostat
  • Zafirlukast
  • Zileuton

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Cranberry Juice
  • Pomegranate
  • Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Avocado
  • Black Tea
  • Enteral Nutrition
  • Green Tea
  • High Protein Food
  • Noni Juice
  • Soybean
  • Vitamin K Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Catheter insertion or
  • Congestive heart failure or
  • Deep venous thrombosis, heparin-induced or
  • Diabetes or
  • Falls or blows to the body or head or
  • Hypertension (high blood pressure) or
  • Infection or
  • Kidney disease, or history of or
  • Major surgery, any type or
  • Polycythemia vera (blood disease) or
  • Protein C deficiency (rare hereditary disease), known or suspected or
  • Stomach or bowel problems, including bleeding or
  • Thrombocytopenia, heparin-induced or
  • Trauma or
  • Vasculitis (inflammation of blood vessel)—Use with caution. May cause side effects to become worse.
  • Blood disease or bleeding problems or
  • Heart infection or
  • High blood pressure (high blood pressure), severe or
  • Spinal anesthesia, recent or
  • Stomach or intestinal ulcer, active or
  • Stroke, history of or
  • Surgery, recent or scheduled (eg, surgery of the eye, brain, or spine) or
  • Threatened miscarriage—Should not be used in patients with these conditions. The risk of bleeding from warfarin may be increased.
  • Diarrhea or
  • Liver disease or
  • Malnutrition or
  • Steatorrhea (fats in the stool) or
  • Vitamin K deficiency—Use with caution. May increase risk of bleeding.

Portions of this document last updated: May 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.