Before Using

Drug information provided by: Merative, Micromedex®

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of estrogens and progestins in the elderly with use in other age groups.

Pregnancy

Estrogens and progestins are not recommended for use during pregnancy or right after giving birth. Becoming pregnant or maintaining a pregnancy is not likely to occur around the time of menopause.

Breastfeeding

Estrogens and progestins pass into the breast milk and can change the content or lower the amount of breast milk. Use of this medicine is not recommended in nursing mothers.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

  • Atazanavir
  • Bepridil
  • Boceprevir
  • Cisapride
  • Cobicistat
  • Cyclosporine
  • Dasabuvir
  • Dronedarone
  • Eltrombopag
  • Enasidenib
  • Fostemsavir
  • Gemfibrozil
  • Grazoprevir
  • Ketoconazole
  • Levoketoconazole
  • Mavacamten
  • Mesoridazine
  • Ombitasvir
  • Paritaprevir
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Ritonavir
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tranexamic Acid
  • Velpatasvir
  • Ziprasidone

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Adagrasib
  • Alfuzosin
  • Alprazolam
  • Amifampridine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amobarbital
  • Amoxicillin
  • Ampicillin
  • Amprenavir
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Aprepitant
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Armodafinil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bacampicillin
  • Bedaquiline
  • Belzutifan
  • Berotralstat
  • Betamethasone
  • Bexarotene
  • Boceprevir
  • Bosentan
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Butabarbital
  • Butalbital
  • Capivasertib
  • Capmatinib
  • Carbamazepine
  • Carbenicillin
  • Carvedilol
  • Cefaclor
  • Cefadroxil
  • Cefdinir
  • Cefditoren
  • Cefixime
  • Cefpodoxime
  • Cefprozil
  • Ceftazidime
  • Ceftibuten
  • Cefuroxime
  • Cenobamate
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Cloxacillin
  • Clozapine
  • Cobicistat
  • Codeine
  • Colesevelam
  • Conivaptan
  • Cosyntropin
  • Crizotinib
  • Cyclacillin
  • Cyclobenzaprine
  • Cyclosporine
  • Dabrafenib
  • Daridorexant
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desogestrel
  • Deutetrabenazine
  • Dexamethasone
  • Dicloxacillin
  • Dienogest
  • Digoxin
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxycycline
  • Droperidol
  • Drospirenone
  • Ebastine
  • Efavirenz
  • Elagolix
  • Elexacaftor
  • Eliglustat
  • Elvitegravir
  • Enasidenib
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Erdafitinib
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Estetrol
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etonogestrel
  • Etravirine
  • Famotidine
  • Fedratinib
  • Felbamate
  • Fentanyl
  • Fexinidazole
  • Finerenone
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluoxetine
  • Formoterol
  • Fosamprenavir
  • Fosaprepitant
  • Foscarnet
  • Fosnetupitant
  • Fosphenytoin
  • Fostemsavir
  • Fruquintinib
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gestodene
  • Glasdegib
  • Glecaprevir
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Grazoprevir
  • Griseofulvin
  • Guar Gum
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Iron
  • Isotretinoin
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Leflunomide
  • Lemborexant
  • Leniolisib
  • Lenvatinib
  • Lesinurad
  • Leuprolide
  • Levofloxacin
  • Levonorgestrel
  • Lixisenatide
  • Lofexidine
  • Lopinavir
  • Lorlatinib
  • Lumacaftor
  • Lumefantrine
  • Macimorelin
  • Mavacamten
  • Medroxyprogesterone
  • Mefloquine
  • Mephobarbital
  • Meropenem
  • Mestranol
  • Methadone
  • Methohexital
  • Methotrimeprazine
  • Metronidazole
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Minocycline
  • Mitapivat
  • Mitotane
  • Mizolastine
  • Mobocertinib
  • Modafinil
  • Moricizine
  • Moxifloxacin
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nafarelin
  • Nafcillin
  • Nefazodone
  • Nelfinavir
  • Netupitant
  • Nevirapine
  • Nilotinib
  • Nirmatrelvir
  • Nirogacestat
  • Nomegestrol
  • Norelgestromin
  • Norethindrone
  • Norfloxacin
  • Norgestimate
  • Norgestrel
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Oliceridine
  • Omaveloxolone
  • Omeprazole
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxacillin
  • Oxaliplatin
  • Oxcarbazepine
  • Oxycodone
  • Oxytetracycline
  • Paclitaxel
  • Paclitaxel Protein-Bound
  • Paliperidone
  • Palovarotene
  • Panobinostat
  • Papaverine
  • Paritaprevir
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Penicillin G
  • Penicillin G Procaine
  • Penicillin V
  • Pentamidine
  • Pentobarbital
  • Perphenazine
  • Phenobarbital
  • Phenylbutazone
  • Phenytoin
  • Pibrentasvir
  • Pimavanserin
  • Pipamperone
  • Piperaquine
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Posaconazole
  • Pralsetinib
  • Praziquantel
  • Prednisolone
  • Prednisone
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Quizartinib
  • Ranolazine
  • Red Clover
  • Repotrectinib
  • Ribociclib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Rosuvastatin
  • Rufinamide
  • Saquinavir
  • Secobarbital
  • Segesterone
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Simeprevir
  • Siponimod
  • Sirolimus Protein-Bound
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Somatrogon-ghla
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Sufentanil
  • Sugammadex
  • Sulpiride
  • Sultamicillin
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tazemetostat
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Teriflunomide
  • Tetrabenazine
  • Tetracycline
  • Theophylline
  • Thiopental
  • Thioridazine
  • Ticarcillin
  • Tigecycline
  • Tipranavir
  • Tirzepatide
  • Tizanidine
  • Tolterodine
  • Topiramate
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trimipramine
  • Triptorelin
  • Trofinetide
  • Troglitazone
  • Ubrogepant
  • Ulipristal
  • Valproic Acid
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Vonoprazan
  • Voriconazole
  • Vorinostat
  • Voxilaprevir
  • Zolpidem
  • Zotepine
  • Zuclopenthixol
  • Zuranolone

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma or
  • Calcium, too much or too little in blood or
  • Diabetes mellitus (sugar diabetes)
  • Epilepsy (seizures) or
  • Heart problems or
  • Kidney problems or
  • Liver tumors, benign or
  • Lupus erythematosus, systemic or
  • Migraine headaches or
  • Porphyria—Estrogens may worsen these conditions.
  • Blood clotting problems (or history of during previous estrogen therapy)—Estrogens usually are not used until blood clotting problems stop; using estrogens is not a problem for most patients without a history of blood clotting problems due to estrogen use.
  • Breast cancer or
  • Bone cancer or
  • Cancer of the uterus or
  • Fibroid tumors of the uterus—Estrogens may interfere with the treatment of breast or bone cancer or worsen cancer of the uterus when these conditions are present.
  • Changes in genital or vaginal bleeding of unknown causes—Use of estrogens may delay diagnosis or worsen condition. The reason for the bleeding should be determined before estrogens are used.
  • Endometriosis or
  • Gallbladder disease or gallstones (or history of) or
  • High cholesterol or triglycerides (or history of) or
  • Liver disease or
  • Pancreatitis (inflammation of pancreas)—Estrogens may worsen these conditions; while estrogens can improve blood cholesterol, they may worsen blood triglycerides for some people.
  • Hypothyroid (too little thyroid hormone)—Dose of thyroid medicine may need to be increased.
  • Vision changes, sudden onset including
  • Bulging eyes or
  • Double vision or
  • Migraine headache or
  • Vision loss, partial or complete—Estrogens may cause these problems. Tell your doctor if you have had any of these problems, especially while taking estrogen or oral contraceptives (“birth control pills”).

Portions of this document last updated: May 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.