Testosterone (Topical Application Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Blood in the urine
2. difficulty urinating
3. frequent urination

Less common

1. Bloating or swelling of the face, arms, hands, lower legs, or feet
2. blurred vision
3. feeling faint, dizzy, or lightheaded
4. feeling of warmth or heat
5. flushing or redness of the skin, especially on the face and neck
6. frequent strong or increased urge to urinate
7. headache
8. nervousness
9. pain, redness, or swelling in the arm or leg
10. pounding in the ears
11. slow or fast heartbeat
12. sweating
13. swelling of the breasts or breast soreness in both females and males
14. tingling of the hands or feet
15. unusual weight gain or loss
16. waking to urinate at night

Incidence not known

1. Aggressive behavior
2. anxiety
3. bluish lips or skin
4. chest pain
5. cough
6. decrease in testicle size
7. development of pubic hair
8. difficult or labored breathing
9. dizziness or lightheadedness
10. enlargement of the clitoris or penis
11. fainting
12. fast heartbeat
13. not breathing
14. pain, redness, or swelling in the arm or leg
15. painful or prolonged erection of the penis
16. tightness in the chest
17. troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Blemishes on the skin
2. burning, itching, redness, skin rash, swelling, or soreness at the application site
3. pimples

Less common

1. Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
2. crying
3. decreased interest in sexual intercourse
4. depression
5. discoloration of the hair
6. dry skin
7. false or unusual sense of well-being
8. hair loss
9. inability to have or keep an erection
10. lack or loss of strength
11. loss in sexual ability, desire, drive, or performance
12. loss of memory
13. paranoia
14. problems with memory
15. quick to react or overreact emotionally
16. rapidly changing moods
17. thinning of the hair

Incidence not known

1. Increased in sexual ability, desire, drive, or performance
2. trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: April 01, 2024

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