打印 概述 典型肾小球和疤痕肾小球 打开弹出式对话框 关闭 典型肾小球和疤痕肾小球 典型肾小球和疤痕肾小球 局灶节段性肾小球硬化(FSGS)由肾小球内形成的疤痕组织引起。肾小球是肾脏内的微小结构,用于从血液中过滤废物并产生尿液。左图所示为健康的肾小球。当肾小球内出现疤痕组织时,肾功能恶化(如右图所示)。 局灶节段性肾小球硬化(FSGS)是一种在肾小球上形成疤痕组织的疾病,肾小球是肾脏的一小部分,用于过滤血液中的废物。FSGS 可由多种因素引起。 FSGS 是一种可导致肾衰竭的严重疾病,只能通过透析或肾移植来治疗。FSGS 的治疗方案取决于疾病的类型。 FSGS 的类型包括: 原发性 FSGS。许多被诊断为 FSGS 的患者并无明确的病因。这叫做原发性(自发性)FSGS。 继发性 FSGS。多种因素(如感染、药物毒性、糖尿病或镰状细胞病等疾病、肥胖症,甚至其他肾脏疾病)可引起继发性 FSGS。对潜在病因进行控制或治疗往往会缓解肾损伤,随着时间的推移可能会改善肾功能。 遗传性 FSGS。这是由基因突变引起的罕见形式的 FSGS。它也被称为家族性 FSGS。当一个家族的几个成员出现 FSGS 症状时,就有可能是遗传性了。当父母双方都没有患病,但各方都携带一个可遗传给下一代的变异基因时,也可能发生家族性 FSGS。 未知 FSGS。在某些情况下,尽管对临床症状进行了评估并进行了广泛的检测,但仍无法确定 FSGS 的根本原因。 产品与服务书籍:《妙佑医疗国际家庭健康手册》第 5 版简报:妙佑医疗国际卫生来信 — 数字版显示妙佑医疗国际的更多产品 症状Symptoms of focal segmental glomerulosclerosis (FSGS) might include: Swelling, called edema, in the legs and ankles, around the eyes and in other body parts. Weight gain from fluid buildup. Foamy urine from protein buildup, called proteinuria. When to see a doctorSee a healthcare professional if you have any of the symptoms of FSGS. 病因局灶节段性肾小球硬化可由多种病症引起,如糖尿病、镰状细胞病、其他肾脏疾病和肥胖症,也可由感染和药物毒性引起。这种罕见的 FSGS 由遗传基因突变引起。有时并无明确的病因。 风险因素Factors that can raise the risk of focal segmental glomerulosclerosis (FSGS) include: Medical conditions that can damage the kidneys. Certain diseases and conditions increase the risk of getting FSGS. These include diabetes, lupus, obesity and other kidney diseases. Certain infections. Infections that increase the risk of FSGS include HIV and hepatitis C. Gene changes. Certain genes passed through families can raise the risk of FSGS. 并发症Focal segmental glomerulosclerosis (FSGS) may lead to other health concerns, also called complications, including: Nephrotic syndrome. This kidney condition causes the body to pass too much protein in the urine. Nephrotic syndrome raises the risk of other health conditions, such as blood clots and high blood pressure. Kidney failure. Damage to the kidneys that can't be fixed causes the kidneys to stop working. The only treatments for kidney failure are dialysis or kidney transplant. 临床试验 探索 Mayo Clinic 的研究 测试新的治疗、干预与检查方法,旨在预防、检测、治疗或控制这种疾病。 来自妙佑医疗国际员工 在 Mayo Clinic 治疗 申请预约 医生与科室 March 08, 2023 打印 Living with 局灶节段性肾小球硬化(fsgs)? Connect with others like you for support and answers to your questions in the Transplants support group on Mayo Clinic Connect, a patient community. Transplants Discussions My Bone Marrow Transplant (BMT/SCT) story: Will you share yours? 363 Replies Thu, May 02, 2024 chevron-right Liver transplant - Let's support each other 1566 Replies Thu, May 02, 2024 chevron-right SPK (simultaneous pancreas and kidney) transplants 73 Replies Wed, May 01, 2024 chevron-right See more discussions 显示参考文献 Focal segmental glomerulosclerosis (FSGS). National Kidney Foundation. https://www.kidney.org/atoz/content/focal. Accessed July 10, 2021. Reiser J. Epidemiology, classification, and pathogenesis of focal segmental glomerulosclerosis. https://www.uptodate.com/contents/search. Accessed July 10, 2021. Yu ASL, et al. Primary glomerular disease. In: Brenner and Rector's The Kidney. 11th ed. Elsevier; 2020. Rosenberg AZ, et al. Focal segmental glomerulosclerosis. Clinical Journal of the American Society of Nephrology. 2017; doi:10.2215/CJN.05960616. Chebib FT (expert opinion). Mayo Clinic. Aug. 8, 2021. What is a kidney biopsy? National Kidney Foundation. https://www.kidney.org/atoz/content/kidney-biopsy. Accessed July 10, 2021. AskMayoExpert. Glomerular disease. Mayo Clinic; 2020. Cattran DC, et al. Treatment of primary focal segmental glomerulosclerosis. https://www.uptodate.com/contents/search. Accessed July 10, 2021. Braswell-Pickering EA. Allscripts EPSi. Mayo Clinic. July 15, 2021. 相关 典型肾小球和疤痕肾小球 产品与服务 书籍:《妙佑医疗国际家庭健康手册》第 5 版 简报:妙佑医疗国际卫生来信 — 数字版 显示更多来自妙佑医疗国际的产品和服务 局灶节段性肾小球硬化(FSGS)症状与病因医生与科室在 Mayo Clinic 治疗 Advertisement 妙佑医疗国际不为任何公司或产品背书。广告收入为我们的非营利使命提供支持。 广告与赞助政策 政策 机会 广告选择 妙佑医疗国际出版社 浏览妙佑医疗国际出版社提供的畅销书以及书籍和简报的特别优惠。 《妙佑医疗国际论失禁》(Mayo Clinic on Incontinence) - 妙佑医疗国际出版社《妙佑医疗国际论失禁》(Mayo Clinic on Incontinence)《糖尿病基本知识》 - 妙佑医疗国际出版社《糖尿病基本知识》妙佑医疗国际论平衡和听觉 - 妙佑医疗国际出版社妙佑医疗国际论平衡和听觉妙佑医疗国际免费饮食方案评估 - 妙佑医疗国际出版社妙佑医疗国际免费饮食方案评估妙佑医疗国际健康通讯 — 免费书籍 - 妙佑医疗国际出版社妙佑医疗国际健康通讯 — 免费书籍 CON-20208703 患者护理和健康信息 疾病与状况 局灶节段性肾小球硬化(FSGS)