Publications Print Miller MJ, Gries KJ, Marcotte GR, Ryan Z, Strub MD, Kunz HE, Arendt BK, Dasari S, Ebert SM, Adams CM, Lanza IR. Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function. Aging Cell. 2024 Apr; 23 (4):e14097 Epub 2024 Jan 31 View PubMed Nath KA, Singh RD, Croatt AJ, Ackerman AW, Grande JP, O'Brien DR, Garovic VD, Adams CM, Tchkonia T, Kirkland JL. Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications. Kidney360. 2024 Apr 1; 5 (4):501-514 Epub 2024 Feb 21 View PubMed Bjorkman SH, Marti A, Jena J, Garcia-Pena LM, Weatherford ET, Kato K, Koneru J, Chen J, Sood A, Potthoff MJ, Adams CM, Abel ED, Pereira RO. ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms. Sci Rep. 2024 Jan 18; 14 (1):1563 View PubMed Ebert SM, Nicolas CS, Schreiber P, Lopez JG, Taylor AT, Judge AR, Judge SM, Rasmussen BB, Talley JJ, Reme CA, Adams CM. Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy. Animals (Basel). 2024 Jan 5; 14 (2) Epub 2024 Jan 05 View PubMed Marcotte GR, Miller MJ, Kunz HE, Ryan ZC, Strub MD, Vanderboom PM, Heppelmann CJ, Chau S, Von Ruff ZD, Kilroe SP, McKeen AT, Dierdorff JM, Stern JI, Nath KA, Grueter CE, Lira VA, Judge AR, Rasmussen BB, Nair KS, Lanza IR, Ebert SM, Adams CM. GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle. JCI Insight. 2023 Nov 22; 8 (22) View PubMed Miller MJ, Marcotte GR, Basisty N, Wehrfritz C, Ryan ZC, Strub MD, McKeen AT, Stern JI, Nath KA, Rasmussen BB, Judge AR, Schilling B, Ebert SM, Adams CM. The transcription regulator ATF4 is a mediator of skeletal muscle aging. Geroscience. 2023 Aug; 45 (4):2525-2543 Epub 2023 Apr 04 View PubMed Gnanaprakasam JNR, Kushwaha B, Liu L, Chen X, Kang S, Wang T, Cassel TA, Adams CM, Higashi RM, Scott DA, Xin G, Li Z, Yang J, Lane AN, Fan TW, Zhang J, Wang R. Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response. Nat Metab. 2023 Aug; 5 (8):1423-1439 Epub 2023 Aug 07 View PubMed Basisty N, Shulman N, Wehrfritz C, Marsh AN, Shah S, Rose J, Ebert S, Miller M, Dai DF, Rabinovitch PS, Adams CM, MacCoss MJ, MacLean B, Schilling B. TurnoveR: A Skyline External Tool for Analysis of Protein Turnover in Metabolic Labeling Studies. J Proteome Res. 2023 Feb 3; 22 (2):311-322 Epub 2022 Sept 27 View PubMed Nath KA, Singh RD, Croatt AJ, Adams CM. Heme Proteins and Kidney Injury: Beyond Rhabdomyolysis. Kidney360. 2022 Nov 24; 3 (11):1969-1979 Epub 2022 Oct 05 View PubMed Singh RD, Croatt AJ, Ackerman AW, Grande JP, Trushina E, Salisbury JL, Christensen TA, Adams CM, Tchkonia T, Kirkland JL, Nath KA. Prominent Mitochondrial Injury as an Early Event in Heme Protein-Induced Acute Kidney Injury. Kidney360. 2022 Oct 27; 3 (10):1672-1682 Epub 2022 Aug 15 View PubMed Wang X, Zhang G, Dasgupta S, Niewold EL, Li C, Li Q, Luo X, Tan L, Ferdous A, Lorenzi PL, Rothermel BA, Gillette TG, Adams CM, Scherer PE, Hill JA, Wang ZV. ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress. Circ Res. 2022 Jun 24; 131 (1):91-105 Epub 2022 May 16 View PubMed Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, Talley JJ, Adams CM. Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. J Nutr. 2022 Apr 1; 152 (4):926-938 View PubMed Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab. 2021 Nov; 53:101309 Epub 2021 July 23 View PubMed Fan Z, Turiel G, Ardicoglu R, Ghobrial M, Masschelein E, Kocijan T, Zhang J, Tan G, Fitzgerald G, Gorski T, Alvarado-Diaz A, Gilardoni P, Adams CM, Ghesquiere B, De Bock K. Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4(+) endothelial cells. Cell Metab. 2021 Sep 7; 33 (9):1793-1807.e9 Epub 2021 Aug 05 View PubMed Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bui Tran W, Garcia-Pena LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. Elife. 2021 May 4; 10 Epub 2021 May 04 View PubMed Damal Villivalam S, Ebert SM, Lim HW, Kim J, You D, Jung BC, Palacios HH, Tcheau T, Adams CM, Kang S. A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress. EMBO J. 2021 May 3; 40 (9):e106491 Epub 2021 Apr 13 View PubMed Rosu A, El Hachem N, Rapino F, Rouault-Pierre K, Jorssen J, Somja J, Ramery E, Thiry M, Nguyen L, Jacquemyn M, Daelemans D, Adams CM, Bonnet D, Chariot A, Close P, Bureau F, Desmet CJ. Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. J Exp Med. 2021 Mar 1; 218 (3) View PubMed Rasmussen BB, Adams CM. ATF4 Is a Fundamental Regulator of Nutrient Sensing and Protein Turnover. J Nutr. 2020 May 1; 150 (5):979-980 View PubMed Ebert SM, Bullard SA, Basisty N, Marcotte GR, Skopec ZP, Dierdorff JM, Al-Zougbi A, Tomcheck KC, DeLau AD, Rathmacher JA, Bodine SC, Schilling B, Adams CM. Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPbeta. J Biol Chem. 2020 Feb 28; 295 (9):2787-2803 Epub 2020 Jan 17 View PubMed Fuqua JD, Mere CP, Kronemberger A, Blomme J, Bae D, Turner KD, Harris MP, Scudese E, Edwards M, Ebert SM, de Sousa LGO, Bodine SC, Yang L, Adams CM, Lira VA. ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle. FASEB J. 2019 Nov; 33 (11):11735-11745 Epub 2019 Aug 09 View PubMed Ebert SM, Dierdorff JM, Meyerholz DK, Bullard SA, Al-Zougbi A, DeLau AD, Tomcheck KC, Skopec ZP, Marcotte GR, Bodine SC, Adams CM. An investigation of p53 in skeletal muscle aging. J Appl Physiol (1985). 2019 Oct 1; 127 (4):1075-1084 Epub 2019 Aug 29 View PubMed Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB. Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. Elife. 2019 Jul 18; 8 Epub 2019 July 18 View PubMed Ebert SM, Al-Zougbi A, Bodine SC, Adams CM. Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies. Physiology (Bethesda). 2019 Jul 1; 34 (4):232-239 View PubMed Munroe M, Dvoretskiy S, Lopez A, Leong J, Dyle MC, Kong H, Adams CM, Boppart MD. Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization. FASEB J. 2019 Jun; 33 (6):7694-7706 Epub 2019 Apr 25 View PubMed Stebounova L, Ebert SM, Murry LT, Adams CM, Murry DJ. Rapid and Sensitive Quantification of Ursolic Acid and Oleanolic Acid in Human Plasma Using Ultra-performance Liquid Chromatography-Mass Spectrometry. J Chromatogr Sci. 2018 Aug 1; 56 (7):644-649 View PubMed Hughes DC, Marcotte GR, Baehr LM, West DWD, Marshall AG, Ebert SM, Davidyan A, Adams CM, Bodine SC, Baar K. Alterations in the muscle force transfer apparatus in aged rats during unloading and reloading: impact of microRNA-31. J Physiol. 2018 Jul; 596 (14):2883-2900 View PubMed Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017 Jul 14; 36 (14):2126-2145 Epub 2017 June 12 View PubMed Adams CM, Ebert SM, Dyle MC. Role of ATF4 in skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care. 2017 May; 20 (3):164-168 View PubMed Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice. J Biol Chem. 2017 Apr 21; 292 (16):6786-6798 Epub 2017 Feb 27 View PubMed Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M. Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. JCI Insight. 2016 Nov 3; 1 (18):e88646 Epub 2016 Nov 03 View PubMed Moro T, Ebert SM, Adams CM, Rasmussen BB. Amino Acid Sensing in Skeletal Muscle. Trends Endocrinol Metab. 2016 Nov; 27 (11):796-806 Epub 2016 July 19 View PubMed Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH. Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence. Am J Physiol Endocrinol Metab. 2016 Sep 1; 311 (3):E594-604 Epub 2016 July 05 View PubMed Bullard SA, Seo S, Schilling B, Dyle MC, Dierdorff JM, Ebert SM, DeLau AD, Gibson BW, Adams CM. Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4. J Biol Chem. 2016 Aug 19; 291 (34):17496-17509 Epub 2016 June 29 View PubMed Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell. 2016 May 1; 27 (9):1536-51 Epub 2016 Mar 09 View PubMed Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015 Oct 16; 290 (42):25497-511 Epub 2015 Sept 03 View PubMed Suneja M, Fox DK, Fink BD, Herlein JA, Adams CM, Sivitz WI. Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy. Transl Res. 2015 Aug; 166 (2):176-87 Epub 2015 Jan 28 View PubMed Adams CM, Ebert SM, Dyle MC. Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care. 2015 May; 18 (3):263-8 View PubMed Bongers KS, Fox DK, Kunkel SD, Stebounova LV, Murry DJ, Pufall MA, Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Adams CM. Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2015 Jan 15; 308 (2):E144-58 Epub 2014 Nov 18 View PubMed Fox DK, Ebert SM, Bongers KS, Dyle MC, Bullard SA, Dierdorff JM, Kunkel SD, Adams CM. p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 1; 307 (3):E245-61 Epub 2014 June 03 View PubMed Dyle MC, Ebert SM, Cook DP, Kunkel SD, Fox DK, Bongers KS, Bullard SA, Dierdorff JM, Adams CM. Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. J Biol Chem. 2014 May 23; 289 (21):14913-24 Epub 2014 Apr 09 View PubMed Bongers KS, Fox DK, Ebert SM, Kunkel SD, Dyle MC, Bullard SA, Dierdorff JM, Adams CM. Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4. Am J Physiol Endocrinol Metab. 2013 Oct 1; 305 (7):E907-15 Epub 2013 Aug 13 View PubMed Ebert SM, Dyle MC, Kunkel SD, Bullard SA, Bongers KS, Fox DK, Dierdorff JM, Foster ED, Adams CM. Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy. J Biol Chem. 2012 Aug 10; 287 (33):27290-301 Epub 2012 June 12 View PubMed Kunkel SD, Elmore CJ, Bongers KS, Ebert SM, Fox DK, Dyle MC, Bullard SA, Adams CM. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One. 2012; 7 (6):e39332 Epub 2012 June 20 View PubMed Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM. mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab. 2011 Jun 8; 13 (6):627-38 View PubMed Adams CM, Suneja M, Dudley-Javoroski S, Shields RK. Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis. Muscle Nerve. 2011 Jan; 43 (1):65-75 View PubMed Ebert SM, Monteys AM, Fox DK, Bongers KS, Shields BE, Malmberg SE, Davidson BL, Suneja M, Adams CM. The transcription factor ATF4 promotes skeletal myofiber atrophy during fasting. Mol Endocrinol. 2010 Apr; 24 (4):790-9 Epub 2010 Mar 02 View PubMed Seo J, Fortuno ES 3rd, Suh JM, Stenesen D, Tang W, Parks EJ, Adams CM, Townes T, Graff JM. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 2009 Nov; 58 (11):2565-73 Epub 2009 Aug 18 View PubMed Malmberg SE, Adams CM. Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake. J Biol Chem. 2008 Jul 11; 283 (28):19229-34 Epub 2008 May 14 View PubMed Adams CM. Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J Biol Chem. 2007 Jun 8; 282 (23):16744-53 Epub 2007 Apr 12 View PubMed Adams CM, Reitz J, De Brabander JK, Feramisco JD, Li L, Brown MS, Goldstein JL. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem. 2004 Dec 10; 279 (50):52772-80 Epub 2004 Sept 27 View PubMed Adams CM, Goldstein JL, Brown MS. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proc Natl Acad Sci U S A. 2003 Sep 16; 100 (19):10647-52 Epub 2003 Sept 08 View PubMed Ainsley JA, Pettus JM, Bosenko D, Gerstein CE, Zinkevich N, Anderson MG, Adams CM, Welsh MJ, Johnson WA. Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr Biol. 2003 Sep 2; 13 (17):1557-63 View PubMed Yabe D, Xia ZP, Adams CM, Rawson RB. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. Proc Natl Acad Sci U S A. 2002 Dec 24; 99 (26):16672-7 Epub 2002 Dec 13 View PubMed Adams CM, Snyder PM, Welsh MJ. Paradoxical stimulation of a DEG/ENaC channel by amiloride. J Biol Chem. 1999 May 28; 274 (22):15500-4 View PubMed Adams CM, Price MP, Snyder PM, Welsh MJ. Tetraethylammonium block of the BNC1 channel. Biophys J. 1999 Mar; 76 (3):1377-83 View PubMed Adams CM, Snyder PM, Price MP, Welsh MJ. Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration. J Biol Chem. 1998 Nov 13; 273 (46):30204-7 View PubMed Goulet CC, Volk KA, Adams CM, Prince LS, Stokes JB, Snyder PM. Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. J Biol Chem. 1998 Nov 6; 273 (45):30012-7 View PubMed Adams CM, Anderson MG, Motto DG, Price MP, Johnson WA, Welsh MJ. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J Cell Biol. 1998 Jan 12; 140 (1):143-52 View PubMed Adams CM, Snyder PM, Welsh MJ. Interactions between subunits of the human epithelial sodium channel. J Biol Chem. 1997 Oct 24; 272 (43):27295-300 View PubMed Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ. Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell. 1995 Dec 15; 83 (6):969-78 View PubMed Dentler WL, Adams C. Flagellar microtubule dynamics in Chlamydomonas: cytochalasin D induces periods of microtubule shortening and elongation; and colchicine induces disassembly of the distal, but not proximal, half of the flagellum. J Cell Biol. 1992 Jun; 117 (6):1289-98 View PubMed PST-20551087 Home Publications