Precautions

Drug information provided by: Merative, Micromedex®

Taking certain other medicines together with ketorolac may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take every day, and on how long you take the medicines together. Therefore, do not take acetaminophen (e.g., Tylenol) together with ketorolac for more than a few days, unless otherwise directed by your medical doctor or dentist. Also, do not take any of the following medicines together with ketorolac, unless your medical doctor or dentist has directed you to do so and is following your progress:

  • Aspirin or other salicylates
  • Diclofenac (e.g., Voltaren®)
  • Diflunisal (e.g., Dolobid®)
  • Etodolac (e.g., Lodine®)
  • Fenoprofen (e.g., Nalfon®)
  • Floctafenine (e.g., Idarac®)
  • Flurbiprofen (e.g., Ansaid®)
  • Ibuprofen (e.g., Motrin®)
  • Indomethacin (e.g., Indocin®)
  • Ketoprofen (e.g., Orudis®)
  • Meclofenamate (e.g., Meclomen®)
  • Mefenamic acid (e.g., Ponstel®)
  • Nabumetone (e.g., Relafen®)
  • Naproxen (e.g., Naprosyn®)
  • Oxaprozin (e.g., Daypro®)
  • Phenylbutazone (e.g., Butazolidin®)
  • Piroxicam (e.g., Feldene®)
  • Sulindac (e.g., Clinoril®)
  • Tenoxicam (e.g., Mobiflex®)
  • Tiaprofenic acid (e.g., Surgam®)
  • Tolmetin (e.g., Tolectin®)
  • Zomepirac (e.g., Zomax®)

Ketorolac may cause some people to become dizzy or drowsy. If either of these side effects occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert.

Serious side effects can occur during treatment with this medicine. Sometimes serious side effects can occur without any warning. However, possible warning signs often occur, including swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, or unusual flushing or warmth of skin. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.